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In vivo hemodynamic and electrocardiographic changes following Crataegus aronia syn. Azarolus L administration to normotensive Wistar rats.
Saudi Med J. 2013 Feb; 34(2):123-34.SM

Abstract

OBJECTIVE

To evaluate the effects of the whole plant aqueous extract of Crataegus aronia (C. aronia) syn. Azarolus (L) on the hemodynamic and electrocardiographic intervals in albino rats.

METHODS

This study was carried out in 2 stages at the Research Laboratory, Physiology Department, Medical College of King Khalid University, Abha, Kingdom of Saudi Arabia between February and June 2012. First, the effects of C. aronia syn. Azarolus (L) on the hemodynamics and electrocardiograph in 54 Wistar male rats were assessed, then the mechanisms underlying the hemodynamic and electrocardiographic changes observed in the first stage were evaluated in 48 rats of the same species.

RESULTS

The C. aronia administered at escalating doses (0.05-20 microgram/kg) produced a dose-time-dependent decrease in heart rate (HR) and mean arterial pressure (MAP). Higher doses (15 and 20 microgram/kg) produced the most significant reduction in both HR and MAP, and induced sinus node suppression and progressive atrio-ventricular blockade. The underlying mechanism of the induced bradyarrhythmia appeared to be due to the direct stimulation of the muscarinic receptor M2 and possible blockade of beta-receptors, while the hypotension was caused by enhanced nitric oxide release. No significant alterations in the electrocardiogram (ECG) components were observed.

CONCLUSION

The administration of the C. aronia syn. Azarolus extract induced bradyarrhythmia and hypotension, without alteration in the ECG components.

Authors+Show Affiliations

Department of Medicine, Cardiology Section, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. asshalghamdi@yahoo.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23396457

Citation

Shatoor, Abdullah S.. "In Vivo Hemodynamic and Electrocardiographic Changes Following Crataegus Aronia Syn. Azarolus L Administration to Normotensive Wistar Rats." Saudi Medical Journal, vol. 34, no. 2, 2013, pp. 123-34.
Shatoor AS. In vivo hemodynamic and electrocardiographic changes following Crataegus aronia syn. Azarolus L administration to normotensive Wistar rats. Saudi Med J. 2013;34(2):123-34.
Shatoor, A. S. (2013). In vivo hemodynamic and electrocardiographic changes following Crataegus aronia syn. Azarolus L administration to normotensive Wistar rats. Saudi Medical Journal, 34(2), 123-34.
Shatoor AS. In Vivo Hemodynamic and Electrocardiographic Changes Following Crataegus Aronia Syn. Azarolus L Administration to Normotensive Wistar Rats. Saudi Med J. 2013;34(2):123-34. PubMed PMID: 23396457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo hemodynamic and electrocardiographic changes following Crataegus aronia syn. Azarolus L administration to normotensive Wistar rats. A1 - Shatoor,Abdullah S, PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2015/4/14/medline SP - 123 EP - 34 JF - Saudi medical journal JO - Saudi Med J VL - 34 IS - 2 N2 - OBJECTIVE: To evaluate the effects of the whole plant aqueous extract of Crataegus aronia (C. aronia) syn. Azarolus (L) on the hemodynamic and electrocardiographic intervals in albino rats. METHODS: This study was carried out in 2 stages at the Research Laboratory, Physiology Department, Medical College of King Khalid University, Abha, Kingdom of Saudi Arabia between February and June 2012. First, the effects of C. aronia syn. Azarolus (L) on the hemodynamics and electrocardiograph in 54 Wistar male rats were assessed, then the mechanisms underlying the hemodynamic and electrocardiographic changes observed in the first stage were evaluated in 48 rats of the same species. RESULTS: The C. aronia administered at escalating doses (0.05-20 microgram/kg) produced a dose-time-dependent decrease in heart rate (HR) and mean arterial pressure (MAP). Higher doses (15 and 20 microgram/kg) produced the most significant reduction in both HR and MAP, and induced sinus node suppression and progressive atrio-ventricular blockade. The underlying mechanism of the induced bradyarrhythmia appeared to be due to the direct stimulation of the muscarinic receptor M2 and possible blockade of beta-receptors, while the hypotension was caused by enhanced nitric oxide release. No significant alterations in the electrocardiogram (ECG) components were observed. CONCLUSION: The administration of the C. aronia syn. Azarolus extract induced bradyarrhythmia and hypotension, without alteration in the ECG components. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/23396457/In_vivo_hemodynamic_and_electrocardiographic_changes_following_Crataegus_aronia_syn__Azarolus_L_administration_to_normotensive_Wistar_rats_ DB - PRIME DP - Unbound Medicine ER -