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Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health.

Abstract

The "A-type" proanthocyanidins in cranberry fruit (Vaccinium macrocarpon Ait.) are bioactive components associated with prevention of urinary tract infections (UTI). Cranberry juice, fruit (fresh and dried), functional foods, and cranberry dietary supplements are promoted for prevention of UTI and for maintenance of urinary tract health (UTH), on the basis of their content of cranberry proanthocyanidins (c-PAC) with "A-type" interflavan bonds. With increasing consumer use of cranberries for maintenance of UTH and an expanding number of commercial cranberry products of different types, the availability of unified methods for measuring levels of c-PAC is important. This review discusses quantitative and qualitative analysis of c-PAC with "A-type" interflavan bonds in relation to their biological activity for UTI prevention. The integrity (including authenticity, standardization, efficacy, and safety) of cranberry fruit, juices, and dietary supplements may now be measured by using recent advances in mass spectrometry, liquid chromatography, production of c-PAC standards, and improved simple quantitative techniques.

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  • Authors+Show Affiliations

    ,

    Complete Phytochemical Solutions, LLC, Cambridge, WI 52523, USA. ckrueger@wisc.edu

    , ,

    Source

    Analytical and bioanalytical chemistry 405:13 2013 May pg 4385-95

    MeSH

    Beverages
    Chromatography, Liquid
    Cinnamates
    Dietary Supplements
    Humans
    Mass Spectrometry
    Plant Extracts
    Proanthocyanidins
    Reference Standards
    Urinary Tract Infections
    Vaccinium macrocarpon

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23397091

    Citation

    Krueger, Christian G., et al. "Quantifying and Characterizing Proanthocyanidins in Cranberries in Relation to Urinary Tract Health." Analytical and Bioanalytical Chemistry, vol. 405, no. 13, 2013, pp. 4385-95.
    Krueger CG, Reed JD, Feliciano RP, et al. Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Anal Bioanal Chem. 2013;405(13):4385-95.
    Krueger, C. G., Reed, J. D., Feliciano, R. P., & Howell, A. B. (2013). Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Analytical and Bioanalytical Chemistry, 405(13), pp. 4385-95. doi:10.1007/s00216-013-6750-3.
    Krueger CG, et al. Quantifying and Characterizing Proanthocyanidins in Cranberries in Relation to Urinary Tract Health. Anal Bioanal Chem. 2013;405(13):4385-95. PubMed PMID: 23397091.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. AU - Krueger,Christian G, AU - Reed,Jess D, AU - Feliciano,Rodrigo P, AU - Howell,Amy B, Y1 - 2013/02/09/ PY - 2012/10/19/received PY - 2013/01/15/accepted PY - 2012/12/12/revised PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2013/10/22/medline SP - 4385 EP - 95 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 405 IS - 13 N2 - The "A-type" proanthocyanidins in cranberry fruit (Vaccinium macrocarpon Ait.) are bioactive components associated with prevention of urinary tract infections (UTI). Cranberry juice, fruit (fresh and dried), functional foods, and cranberry dietary supplements are promoted for prevention of UTI and for maintenance of urinary tract health (UTH), on the basis of their content of cranberry proanthocyanidins (c-PAC) with "A-type" interflavan bonds. With increasing consumer use of cranberries for maintenance of UTH and an expanding number of commercial cranberry products of different types, the availability of unified methods for measuring levels of c-PAC is important. This review discusses quantitative and qualitative analysis of c-PAC with "A-type" interflavan bonds in relation to their biological activity for UTI prevention. The integrity (including authenticity, standardization, efficacy, and safety) of cranberry fruit, juices, and dietary supplements may now be measured by using recent advances in mass spectrometry, liquid chromatography, production of c-PAC standards, and improved simple quantitative techniques. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/23397091/Quantifying_and_characterizing_proanthocyanidins_in_cranberries_in_relation_to_urinary_tract_health_ L2 - https://dx.doi.org/10.1007/s00216-013-6750-3 DB - PRIME DP - Unbound Medicine ER -