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A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease.
Semin Liver Dis 2012; 32(4):317-24SL

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in children; its rise has been related to the increasing prevalence of obesity. Significant advancements have been made in the investigation of the etiopathogenesis and genetic risk factors for the disease. Pediatric fatty liver disease often displays a histologic pattern distinct from that found in adults, and liver biopsy remains the gold standard for diagnosis of nonalcoholic steatohepatitis (NASH). Lifestyle modifications that result in weight loss remain the first-line treatment of NAFLD in children. Recent adult and pediatric clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD have demonstrated encouraging results, and additional trials are underway. In this review, the authors provide an overview of current concepts in epidemiology, histologic features, diagnosis, pathophysiology, genetic risk factors, and treatment of NAFLD in children.

Authors+Show Affiliations

Department of Pediatrics, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. no2021@columbia.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23397532

Citation

Ovchinsky, Nadia, and Joel E. Lavine. "A Critical Appraisal of Advances in Pediatric Nonalcoholic Fatty Liver Disease." Seminars in Liver Disease, vol. 32, no. 4, 2012, pp. 317-24.
Ovchinsky N, Lavine JE. A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease. Semin Liver Dis. 2012;32(4):317-24.
Ovchinsky, N., & Lavine, J. E. (2012). A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease. Seminars in Liver Disease, 32(4), pp. 317-24. doi:10.1055/s-0032-1329905.
Ovchinsky N, Lavine JE. A Critical Appraisal of Advances in Pediatric Nonalcoholic Fatty Liver Disease. Semin Liver Dis. 2012;32(4):317-24. PubMed PMID: 23397532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease. AU - Ovchinsky,Nadia, AU - Lavine,Joel E, Y1 - 2013/02/08/ PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2013/7/31/medline SP - 317 EP - 24 JF - Seminars in liver disease JO - Semin. Liver Dis. VL - 32 IS - 4 N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in children; its rise has been related to the increasing prevalence of obesity. Significant advancements have been made in the investigation of the etiopathogenesis and genetic risk factors for the disease. Pediatric fatty liver disease often displays a histologic pattern distinct from that found in adults, and liver biopsy remains the gold standard for diagnosis of nonalcoholic steatohepatitis (NASH). Lifestyle modifications that result in weight loss remain the first-line treatment of NAFLD in children. Recent adult and pediatric clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD have demonstrated encouraging results, and additional trials are underway. In this review, the authors provide an overview of current concepts in epidemiology, histologic features, diagnosis, pathophysiology, genetic risk factors, and treatment of NAFLD in children. SN - 1098-8971 UR - https://www.unboundmedicine.com/medline/citation/23397532/A_critical_appraisal_of_advances_in_pediatric_nonalcoholic_Fatty_liver_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1329905 DB - PRIME DP - Unbound Medicine ER -