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Antioxidant supplementation for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials.
Nutr J. 2013 Feb 11; 12:23.NJ

Abstract

BACKGROUND

Acute pancreatitis remains the most common major complication of endoscopic retrograde cholangiopancreatography (ERCP). The pathogenesis of post-ERCP acute pancreatitis may be mediated by oxygen-derived free radicals, which could be ameliorated by antioxidants. Antioxidant supplementation may potentially prevent post-ERCP pancreatitis. We performed a meta-analysis of randomized controlled trials to evaluate the effect of prophylactic antioxidant supplementation compared with control on the prevention of post-ERCP pancreatitis.

METHODS

PubMed and Embase databases were searched to identify relevant trials. A standardized Excel file was used to extract data by two independent authors. Results were expressed as risk ratio (RR) with accompanying 95% confidence interval (CI). The meta-analysis was performed with the fixed-effects model or random-effects model according to heterogeneity.

RESULTS

Eleven studies involving 3,010 patients met our inclusion criteria. Antioxidant supplementation did not significantly decrease the incidence of post-ERCP pancreatitis (RR, 0.92; 95% CI, 0.65-1.32; P = 0.665). There was also no statistical difference in the severity grades between the antioxidant group and control group.

CONCLUSIONS

Based on current evidence, antioxidant supplementation shows no beneficial effect on the incidence and the severity of post-ERCP pancreatitis; thus, there is currently a lack of evidence to support using antioxidants for the prevention of post-ERCP pancreatitis.

Authors+Show Affiliations

Department of Anaesthesiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23398675

Citation

Gu, Wan-Jie, et al. "Antioxidant Supplementation for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: a Meta-analysis of Randomized Controlled Trials." Nutrition Journal, vol. 12, 2013, p. 23.
Gu WJ, Wei CY, Yin RX. Antioxidant supplementation for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials. Nutr J. 2013;12:23.
Gu, W. J., Wei, C. Y., & Yin, R. X. (2013). Antioxidant supplementation for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials. Nutrition Journal, 12, 23. https://doi.org/10.1186/1475-2891-12-23
Gu WJ, Wei CY, Yin RX. Antioxidant Supplementation for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: a Meta-analysis of Randomized Controlled Trials. Nutr J. 2013 Feb 11;12:23. PubMed PMID: 23398675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant supplementation for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a meta-analysis of randomized controlled trials. AU - Gu,Wan-Jie, AU - Wei,Chun-Yin, AU - Yin,Rui-Xing, Y1 - 2013/02/11/ PY - 2012/09/04/received PY - 2013/01/25/accepted PY - 2013/2/13/entrez PY - 2013/2/13/pubmed PY - 2013/7/13/medline SP - 23 EP - 23 JF - Nutrition journal JO - Nutr J VL - 12 N2 - BACKGROUND: Acute pancreatitis remains the most common major complication of endoscopic retrograde cholangiopancreatography (ERCP). The pathogenesis of post-ERCP acute pancreatitis may be mediated by oxygen-derived free radicals, which could be ameliorated by antioxidants. Antioxidant supplementation may potentially prevent post-ERCP pancreatitis. We performed a meta-analysis of randomized controlled trials to evaluate the effect of prophylactic antioxidant supplementation compared with control on the prevention of post-ERCP pancreatitis. METHODS: PubMed and Embase databases were searched to identify relevant trials. A standardized Excel file was used to extract data by two independent authors. Results were expressed as risk ratio (RR) with accompanying 95% confidence interval (CI). The meta-analysis was performed with the fixed-effects model or random-effects model according to heterogeneity. RESULTS: Eleven studies involving 3,010 patients met our inclusion criteria. Antioxidant supplementation did not significantly decrease the incidence of post-ERCP pancreatitis (RR, 0.92; 95% CI, 0.65-1.32; P = 0.665). There was also no statistical difference in the severity grades between the antioxidant group and control group. CONCLUSIONS: Based on current evidence, antioxidant supplementation shows no beneficial effect on the incidence and the severity of post-ERCP pancreatitis; thus, there is currently a lack of evidence to support using antioxidants for the prevention of post-ERCP pancreatitis. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/23398675/Antioxidant_supplementation_for_the_prevention_of_post_endoscopic_retrograde_cholangiopancreatography_pancreatitis:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-23 DB - PRIME DP - Unbound Medicine ER -