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Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.

Abstract

This study evaluates the influenza vaccine effectiveness (VE) in preventing laboratory-confirmed cases in Navarre, Spain, in the 2011/12 season in which the peak was delayed until week 7 of 2012. We conducted a test-negative case–control study. Patients with influenza-like illness in hospitals and primary healthcare were swabbed for testing by reverse transcription-polymerase chain reaction. Influenza vaccination status and other covariates were obtained from healthcare databases. The vaccination status of confirmed cases and negative controls was compared after adjusting for potential confounders. VE was calculated as (1-odds ratio)x100. The 411 confirmed cases (93% influenza A(H3)) were compared with 346 controls. Most characterised viruses did not match the vaccine strains. The adjusted estimate of VE was 31% (95% confidence interval (CI): -21 to 60) for all patients, 44% (95% CI: -11 to 72) for those younger than 65 years and 19% (95% CI: -146 to 73) for those 65 or older. The VE was 61% (95% CI: 5 to 84) in the first 100 days after vaccination, 42% (95% CI: -39 to 75) between 100 and 119 days, and zero thereafter. This decline mainly affected people aged 65 or over. These results suggest a low preventive effect of the 2011/12 seasonal influenza vaccine, and a decline in VE with time since vaccination.

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  • Authors+Show Affiliations

    ,

    Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona, Spain. jcastilc@navarra.es

    , , , , , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Case-Control Studies
    Child
    Child, Preschool
    Confidence Intervals
    Female
    Humans
    Incidence
    Infant
    Infant, Newborn
    Influenza A virus
    Influenza Vaccines
    Influenza, Human
    Logistic Models
    Male
    Middle Aged
    Primary Health Care
    Reverse Transcriptase Polymerase Chain Reaction
    Seasons
    Sentinel Surveillance
    Spain
    Time Factors
    Treatment Outcome
    Vaccination
    Young Adult

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23399423

    Citation

    Castilla, J, et al. "Decline in Influenza Vaccine Effectiveness With Time After Vaccination, Navarre, Spain, Season 2011/12." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 18, no. 5, 2013.
    Castilla J, Martínez-Baz I, Martínez-Artola V, et al. Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12. Euro Surveill. 2013;18(5).
    Castilla, J., Martínez-Baz, I., Martínez-Artola, V., Reina, G., Pozo, F., García Cenoz, M., ... Barricarte, A. (2013). Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 18(5).
    Castilla J, et al. Decline in Influenza Vaccine Effectiveness With Time After Vaccination, Navarre, Spain, Season 2011/12. Euro Surveill. 2013 Jan 31;18(5) PubMed PMID: 23399423.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12. AU - Castilla,J, AU - Martínez-Baz,I, AU - Martínez-Artola,V, AU - Reina,G, AU - Pozo,F, AU - García Cenoz,M, AU - Guevara,M, AU - Morán,J, AU - Irisarri,F, AU - Arriazu,M, AU - Albéniz,E, AU - Ezpeleta,C, AU - Barricarte,A, AU - ,, AU - ,, Y1 - 2013/01/31/ PY - 2013/2/13/entrez PY - 2013/2/13/pubmed PY - 2013/4/10/medline JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill. VL - 18 IS - 5 N2 - This study evaluates the influenza vaccine effectiveness (VE) in preventing laboratory-confirmed cases in Navarre, Spain, in the 2011/12 season in which the peak was delayed until week 7 of 2012. We conducted a test-negative case–control study. Patients with influenza-like illness in hospitals and primary healthcare were swabbed for testing by reverse transcription-polymerase chain reaction. Influenza vaccination status and other covariates were obtained from healthcare databases. The vaccination status of confirmed cases and negative controls was compared after adjusting for potential confounders. VE was calculated as (1-odds ratio)x100. The 411 confirmed cases (93% influenza A(H3)) were compared with 346 controls. Most characterised viruses did not match the vaccine strains. The adjusted estimate of VE was 31% (95% confidence interval (CI): -21 to 60) for all patients, 44% (95% CI: -11 to 72) for those younger than 65 years and 19% (95% CI: -146 to 73) for those 65 or older. The VE was 61% (95% CI: 5 to 84) in the first 100 days after vaccination, 42% (95% CI: -39 to 75) between 100 and 119 days, and zero thereafter. This decline mainly affected people aged 65 or over. These results suggest a low preventive effect of the 2011/12 seasonal influenza vaccine, and a decline in VE with time since vaccination. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/23399423/Decline_in_influenza_vaccine_effectiveness_with_time_after_vaccination_Navarre_Spain_season_2011/12_ L2 - http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20388 DB - PRIME DP - Unbound Medicine ER -