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Deformation properties of pharmaceutical excipients determined using an in-die and out-die method.
Int J Pharm. 2013 Mar 25; 446(1-2):6-15.IJ

Abstract

This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (w/w) filler, the rest consisted of dry binder and an antiadhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die method-comparison revealed that the differences are a consequence of the material's elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material's mechanical properties for better elucidation of deformation mechanisms.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, Ljubljana, Slovenia. ilija.ilic@ffa.uni-lj.siNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23402976

Citation

Ilić, Ilija, et al. "Deformation Properties of Pharmaceutical Excipients Determined Using an In-die and Out-die Method." International Journal of Pharmaceutics, vol. 446, no. 1-2, 2013, pp. 6-15.
Ilić I, Govedarica B, Šibanc R, et al. Deformation properties of pharmaceutical excipients determined using an in-die and out-die method. Int J Pharm. 2013;446(1-2):6-15.
Ilić, I., Govedarica, B., Šibanc, R., Dreu, R., & Srčič, S. (2013). Deformation properties of pharmaceutical excipients determined using an in-die and out-die method. International Journal of Pharmaceutics, 446(1-2), 6-15. https://doi.org/10.1016/j.ijpharm.2013.02.001
Ilić I, et al. Deformation Properties of Pharmaceutical Excipients Determined Using an In-die and Out-die Method. Int J Pharm. 2013 Mar 25;446(1-2):6-15. PubMed PMID: 23402976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deformation properties of pharmaceutical excipients determined using an in-die and out-die method. AU - Ilić,Ilija, AU - Govedarica,Biljana, AU - Šibanc,Rok, AU - Dreu,Rok, AU - Srčič,Stane, Y1 - 2013/02/10/ PY - 2012/10/03/received PY - 2013/01/30/revised PY - 2013/02/01/accepted PY - 2013/2/14/entrez PY - 2013/2/14/pubmed PY - 2013/9/6/medline SP - 6 EP - 15 JF - International journal of pharmaceutics JO - Int J Pharm VL - 446 IS - 1-2 N2 - This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (w/w) filler, the rest consisted of dry binder and an antiadhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die method-comparison revealed that the differences are a consequence of the material's elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material's mechanical properties for better elucidation of deformation mechanisms. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/23402976/Deformation_properties_of_pharmaceutical_excipients_determined_using_an_in_die_and_out_die_method_ DB - PRIME DP - Unbound Medicine ER -