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Differential densities of cholinergic nerves in canine supraventricular regions of hearts.
J Cardiol. 2013 Mar; 61(3):232-6.JC

Abstract

PURPOSE

Cholinergic nerve plays an important role in the induction and maintenance of atrial fibrillation (AF). Cholinergic innervation at supraventricular tissues is considered to be the histological basis and intervention-associated target site for the arrhythmia; however, the distribution of cholinergic nerve in supraventricular tissues has not been clearly studied. In this study, we investigated the cholinergic nerve innervation in canine supraventricular regions of hearts.

METHODS

We performed histological and immunohistochemical staining on canine tissues of left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), atrial septum (AS), crista terminalis (CT), pulmonary vein (PV), and super vena cava (SVC) using hematoxylin and eosin (H&E) and antibodies to choline acetyltransferase.

RESULTS

Normal canine cardiovascular histological structures were shown from H&E staining. Cholinergic nerve densities at LAA and RAA were significantly higher than LA, which was higher than RA, but no significant difference was observed between LAA and RAA. Furthermore, RA was significantly higher than AS, CT, PV, and SVC and there were no significant differences among the latter four.

CONCLUSION

The heterogeneity of different densities of cholinergic nerve innervation of canine supraventricular regions establishes the histological basis of cholinergic nerve-mediated pathological conditions.

Links

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Authors+Show Affiliations

Li Z
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhao QY
No affiliation info available
Huang H
No affiliation info available
Yang B
No affiliation info available
Jiang H
No affiliation info available
Huang CX
No affiliation info available

MeSH

AnimalsAtrial FibrillationCholinergic NeuronsDogsHeartImage Processing, Computer-AssistedImmunohistochemistryMale

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23403370

Citation

Li, Zhe, et al. "Differential Densities of Cholinergic Nerves in Canine Supraventricular Regions of Hearts." Journal of Cardiology, vol. 61, no. 3, 2013, pp. 232-6.
Li Z, Zhao QY, Huang H, et al. Differential densities of cholinergic nerves in canine supraventricular regions of hearts. J Cardiol. 2013;61(3):232-6.
Li, Z., Zhao, Q. Y., Huang, H., Yang, B., Jiang, H., & Huang, C. X. (2013). Differential densities of cholinergic nerves in canine supraventricular regions of hearts. Journal of Cardiology, 61(3), 232-6. https://doi.org/10.1016/j.jjcc.2012.12.003
Li Z, et al. Differential Densities of Cholinergic Nerves in Canine Supraventricular Regions of Hearts. J Cardiol. 2013;61(3):232-6. PubMed PMID: 23403370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential densities of cholinergic nerves in canine supraventricular regions of hearts. AU - Li,Zhe, AU - Zhao,Qing-Yan, AU - Huang,He, AU - Yang,Bo, AU - Jiang,Hong, AU - Huang,Cong-Xin, Y1 - 2013/02/09/ PY - 2012/08/05/received PY - 2012/11/13/revised PY - 2012/12/04/accepted PY - 2013/2/14/entrez PY - 2013/2/14/pubmed PY - 2013/9/26/medline SP - 232 EP - 6 JF - Journal of cardiology JO - J Cardiol VL - 61 IS - 3 N2 - PURPOSE: Cholinergic nerve plays an important role in the induction and maintenance of atrial fibrillation (AF). Cholinergic innervation at supraventricular tissues is considered to be the histological basis and intervention-associated target site for the arrhythmia; however, the distribution of cholinergic nerve in supraventricular tissues has not been clearly studied. In this study, we investigated the cholinergic nerve innervation in canine supraventricular regions of hearts. METHODS: We performed histological and immunohistochemical staining on canine tissues of left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), atrial septum (AS), crista terminalis (CT), pulmonary vein (PV), and super vena cava (SVC) using hematoxylin and eosin (H&E) and antibodies to choline acetyltransferase. RESULTS: Normal canine cardiovascular histological structures were shown from H&E staining. Cholinergic nerve densities at LAA and RAA were significantly higher than LA, which was higher than RA, but no significant difference was observed between LAA and RAA. Furthermore, RA was significantly higher than AS, CT, PV, and SVC and there were no significant differences among the latter four. CONCLUSION: The heterogeneity of different densities of cholinergic nerve innervation of canine supraventricular regions establishes the histological basis of cholinergic nerve-mediated pathological conditions. SN - 1876-4738 UR - https://www.unboundmedicine.com/medline/citation/23403370/Differential_densities_of_cholinergic_nerves_in_canine_supraventricular_regions_of_hearts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0914-5087(13)00006-3 DB - PRIME DP - Unbound Medicine ER -