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[Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome].
Zhonghua Nan Ke Xue. 2012 Dec; 18(12):1088-92.ZN

Abstract

OBJECTIVE

To assess the diagnostic value and potentially protective capacity of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and heat-shock protein 70 (HSP70) in chronic bacterial prostatitis (CBP) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

METHODS

We determined the levels of cytokines TNF-alpha, IL-1beta and HSP70 by ELISA in the seminal plasma of 150 men: 36 with CBP, 43 with CP/CPPS IIIA, 46 with CP/CPPS IIIB, and 25 healthy controls. We analyzed the correlation of the HSP70 expression in the CBP and CP/CPPS patients with the chronic prostatitis symptom index (CPSI).

RESULTS

Significantly increased levels of TNF-alpha, IL-1beta and HSP70 were observed in the seminal plasma of the CBP patients as compared with the CP/CPPS patients and healthy controls. The expression of IL-1beta was significantly higher in the patients with CP/CPPS IIIA than in those with CP/CPPS III B and the controls, while the HSP70 level remarkably lower in those with CP/CPPS than in the controls, and its concentration in the seminal plasma of the CBP patients was negatively correlated with CPSI.

CONCLUSION

The levels of HSP70 and IL-1beta in the seminal plasma appear to be most reliable molecular biological markers for the diagnosis of CBP and CP/CPPS, respectively. HSP7O has an important protective role in the regulation of cell functions in CBP patients. CP/CPPS is probably detrimental to the function of T cells and consequently suppresses the expression of HSP70.

Authors+Show Affiliations

Department of Urology, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

23405788

Citation

Guo, Hui, et al. "[Levels of Cytokines and Heat-shock Protein 70 in the Seminal Plasma of Patients With Chronic Bacterial Prostatitis and Chronic Prostatitis/chronic Pelvic Pain Syndrome]." Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 18, no. 12, 2012, pp. 1088-92.
Guo H, Xu YM, Ye ZQ, et al. [Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome]. Zhonghua Nan Ke Xue. 2012;18(12):1088-92.
Guo, H., Xu, Y. M., Ye, Z. Q., & Yu, J. H. (2012). [Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome]. Zhonghua Nan Ke Xue = National Journal of Andrology, 18(12), 1088-92.
Guo H, et al. [Levels of Cytokines and Heat-shock Protein 70 in the Seminal Plasma of Patients With Chronic Bacterial Prostatitis and Chronic Prostatitis/chronic Pelvic Pain Syndrome]. Zhonghua Nan Ke Xue. 2012;18(12):1088-92. PubMed PMID: 23405788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome]. AU - Guo,Hui, AU - Xu,Yue-Min, AU - Ye,Zhang-Qun, AU - Yu,Jian-Hua, PY - 2013/2/15/entrez PY - 2013/2/15/pubmed PY - 2013/9/13/medline SP - 1088 EP - 92 JF - Zhonghua nan ke xue = National journal of andrology JO - Zhonghua Nan Ke Xue VL - 18 IS - 12 N2 - OBJECTIVE: To assess the diagnostic value and potentially protective capacity of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and heat-shock protein 70 (HSP70) in chronic bacterial prostatitis (CBP) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: We determined the levels of cytokines TNF-alpha, IL-1beta and HSP70 by ELISA in the seminal plasma of 150 men: 36 with CBP, 43 with CP/CPPS IIIA, 46 with CP/CPPS IIIB, and 25 healthy controls. We analyzed the correlation of the HSP70 expression in the CBP and CP/CPPS patients with the chronic prostatitis symptom index (CPSI). RESULTS: Significantly increased levels of TNF-alpha, IL-1beta and HSP70 were observed in the seminal plasma of the CBP patients as compared with the CP/CPPS patients and healthy controls. The expression of IL-1beta was significantly higher in the patients with CP/CPPS IIIA than in those with CP/CPPS III B and the controls, while the HSP70 level remarkably lower in those with CP/CPPS than in the controls, and its concentration in the seminal plasma of the CBP patients was negatively correlated with CPSI. CONCLUSION: The levels of HSP70 and IL-1beta in the seminal plasma appear to be most reliable molecular biological markers for the diagnosis of CBP and CP/CPPS, respectively. HSP7O has an important protective role in the regulation of cell functions in CBP patients. CP/CPPS is probably detrimental to the function of T cells and consequently suppresses the expression of HSP70. SN - 1009-3591 UR - https://www.unboundmedicine.com/medline/citation/23405788/[Levels_of_cytokines_and_heat_shock_protein_70_in_the_seminal_plasma_of_patients_with_chronic_bacterial_prostatitis_and_chronic_prostatitis/chronic_pelvic_pain_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/9702 DB - PRIME DP - Unbound Medicine ER -