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Six-minute walk test reflects neurohormonal activation and right ventricular function in systemic sclerosis patients.
Clin Exp Rheumatol. 2013 Mar-Apr; 31(2 Suppl 76):18-23.CE

Abstract

OBJECTIVES

Heart and pulmonary involvement is a leading cause of systemic sclerosis (SSc)-related deaths. The six-minute walk test (6MWT) is a simple and reproducible test commonly used to evaluate exercise capacity. We tried to assess a potential relationship between exercise capacity assessed by 6MWT, echocardiographic parameters of right ventricular function and serum levels of endothelin-1 and NTproBNP.

METHODS

We prospectively studied 111 consecutive patients (101F, 10M, age 54.2±13.8 years) with diagnosed SSc (mean disease duration 9±12.4 years) and a group of 21 age-matched subjects (18F, 3M, age 49.3±10.5 years). In addition to routine evaluation, 6MWT and transthoracic echocardiography (Phillips iE 33) were performed. We also measured serum endothelin-1 (Human Endothelin-1 immunoassay R & D Systems) and NT-proBNP levels (Elecsys pro-BNP immunoassay; Roche Diagnostics).

RESULTS

The mean 6MWT distance was significantly shorter in the SSc group than in the controls (562.8±60.3 vs. 514.7±102.5 m, p=0.03). In the SSc group 6MWT distance correlated with ET-1 (r=-0.5, p<0.0001), NTproBNP (r=-0.4, p=0.0008) levels, and echocardiographic indices AcT (r=0.4, p=0.0002) and TRPG (r=-0.4, p=0.0011). Moreover, in patients with 6MWT distance <450 m NTproBNP and endotothelin-1 levels were significantly higher than in patients with distance >450 m (311.2, 31.1-17237 vs. 105.3, 5-17670 pg/ml, p=0.0138 and 2.9±2.2 vs. 1.4±0.7 pg/ml, p=0.0032).

CONCLUSIONS

Decreased exercise capacity significantly correlates with biochemical and echocardiographic parameters of right ventricular dysfunction and neurohormonal activation providing a potential link for neuroendocrine derangement in patients with SSc.

Authors+Show Affiliations

Medical University of Warsaw, Department of Internal Medicine and Cardiology, Warsaw, Poland. kirzyk35575@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23406664

Citation

Irzyk, Katarzyna, et al. "Six-minute Walk Test Reflects Neurohormonal Activation and Right Ventricular Function in Systemic Sclerosis Patients." Clinical and Experimental Rheumatology, vol. 31, no. 2 Suppl 76, 2013, pp. 18-23.
Irzyk K, Bienias P, Kostrubiec M, et al. Six-minute walk test reflects neurohormonal activation and right ventricular function in systemic sclerosis patients. Clin Exp Rheumatol. 2013;31(2 Suppl 76):18-23.
Irzyk, K., Bienias, P., Kostrubiec, M., Rymarczyk, Z., Bartoszewicz, Z., Siwicka, M., Stelmaszczyk-Emmel, A., Górska, E., Demkow, U., Pruszczyk, P., & Ciurzyński, M. (2013). Six-minute walk test reflects neurohormonal activation and right ventricular function in systemic sclerosis patients. Clinical and Experimental Rheumatology, 31(2 Suppl 76), 18-23.
Irzyk K, et al. Six-minute Walk Test Reflects Neurohormonal Activation and Right Ventricular Function in Systemic Sclerosis Patients. Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):18-23. PubMed PMID: 23406664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six-minute walk test reflects neurohormonal activation and right ventricular function in systemic sclerosis patients. AU - Irzyk,Katarzyna, AU - Bienias,Piotr, AU - Kostrubiec,Maciej, AU - Rymarczyk,Zuzanna, AU - Bartoszewicz,Zbigniew, AU - Siwicka,Maria, AU - Stelmaszczyk-Emmel,Anna, AU - Górska,Elzbieta, AU - Demkow,Urszula, AU - Pruszczyk,Piotr, AU - Ciurzyński,Michal, Y1 - 2013/02/13/ PY - 2012/05/17/received PY - 2012/09/26/accepted PY - 2013/2/15/entrez PY - 2013/2/15/pubmed PY - 2013/9/11/medline SP - 18 EP - 23 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 31 IS - 2 Suppl 76 N2 - OBJECTIVES: Heart and pulmonary involvement is a leading cause of systemic sclerosis (SSc)-related deaths. The six-minute walk test (6MWT) is a simple and reproducible test commonly used to evaluate exercise capacity. We tried to assess a potential relationship between exercise capacity assessed by 6MWT, echocardiographic parameters of right ventricular function and serum levels of endothelin-1 and NTproBNP. METHODS: We prospectively studied 111 consecutive patients (101F, 10M, age 54.2±13.8 years) with diagnosed SSc (mean disease duration 9±12.4 years) and a group of 21 age-matched subjects (18F, 3M, age 49.3±10.5 years). In addition to routine evaluation, 6MWT and transthoracic echocardiography (Phillips iE 33) were performed. We also measured serum endothelin-1 (Human Endothelin-1 immunoassay R & D Systems) and NT-proBNP levels (Elecsys pro-BNP immunoassay; Roche Diagnostics). RESULTS: The mean 6MWT distance was significantly shorter in the SSc group than in the controls (562.8±60.3 vs. 514.7±102.5 m, p=0.03). In the SSc group 6MWT distance correlated with ET-1 (r=-0.5, p<0.0001), NTproBNP (r=-0.4, p=0.0008) levels, and echocardiographic indices AcT (r=0.4, p=0.0002) and TRPG (r=-0.4, p=0.0011). Moreover, in patients with 6MWT distance <450 m NTproBNP and endotothelin-1 levels were significantly higher than in patients with distance >450 m (311.2, 31.1-17237 vs. 105.3, 5-17670 pg/ml, p=0.0138 and 2.9±2.2 vs. 1.4±0.7 pg/ml, p=0.0032). CONCLUSIONS: Decreased exercise capacity significantly correlates with biochemical and echocardiographic parameters of right ventricular dysfunction and neurohormonal activation providing a potential link for neuroendocrine derangement in patients with SSc. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/23406664/Six_minute_walk_test_reflects_neurohormonal_activation_and_right_ventricular_function_in_systemic_sclerosis_patients_ L2 - http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=23406664 DB - PRIME DP - Unbound Medicine ER -