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Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values.
Allergy Asthma Proc. 2013 Jan-Feb; 34(1):e14-20.AA

Abstract

Small airways are relevant to the pathophysiology of asthma. We investigated whether in asthmatic patients with normal forced expiratory volume in the 1st second (FEV(1)) values, impulse oscillometry system (IOS), as a measure of small airway function, contributed additional information to spirometry either at baseline or after bronchodilator, and whether it was related to the disease control. The fall in resistance from 5 to 20 Hz (R5-R20) and reactance at 5 Hz (X5) by IOS and spirometry measures of small airway function (forced expiratory flow at 25-75% [FEF(25-75)] and forced vital capacity/slow inspiratory vital capacity [FVC/SVC]) at baseline and after 400 micrograms of salbutamol were prospectively measured in 33 asthmatic patients (18 women; age range, 18-66 years). Disease control was assessed by the Asthma Control Test (ACT). R5-R20 but not X5 values were significantly related to FEF(25-75) and FVC/SVC values (p < 0.05 for both correlations). When the bronchodilator response was assessed, no correlation was found among IOS and spirometry changes. ACT scores were related to R5-R20, FEF(25-75), and FVC/SVC values (p < 0.01 for all correlations). In asthmatic patients with normal FEV(1) values, R5-R20 values were related to spirometry measures of small airway function. However, when the bronchodilator response was assessed, IOS and spirometry provided quite different results. Moreover, small airway dysfunction, as assessed by IOS and spirometry, was associated with poor disease control and history of asthma exacerbations. The results of this study confirm the value of IOS, as an investigative tool, and suggest that in asthmatic patients with normal FEV(1) values and poor disease control, small airway function should be investigated.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23406931

Citation

Pisi, Roberta, et al. "Small Airway Dysfunction By Impulse Oscillometry in Asthmatic Patients With Normal Forced Expiratory Volume in the 1st Second Values." Allergy and Asthma Proceedings, vol. 34, no. 1, 2013, pp. e14-20.
Pisi R, Tzani P, Aiello M, et al. Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values. Allergy Asthma Proc. 2013;34(1):e14-20.
Pisi, R., Tzani, P., Aiello, M., Martinelli, E., Marangio, E., Nicolini, G., Olivieri, D., & Chetta, A. (2013). Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values. Allergy and Asthma Proceedings, 34(1), e14-20. https://doi.org/10.2500/aap.2013.34.3641
Pisi R, et al. Small Airway Dysfunction By Impulse Oscillometry in Asthmatic Patients With Normal Forced Expiratory Volume in the 1st Second Values. Allergy Asthma Proc. 2013;34(1):e14-20. PubMed PMID: 23406931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values. AU - Pisi,Roberta, AU - Tzani,Panagiota, AU - Aiello,Marina, AU - Martinelli,Enrico, AU - Marangio,Emilio, AU - Nicolini,Gabriele, AU - Olivieri,Dario, AU - Chetta,Alfredo, PY - 2013/2/15/entrez PY - 2013/2/15/pubmed PY - 2013/8/7/medline SP - e14 EP - 20 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 34 IS - 1 N2 - Small airways are relevant to the pathophysiology of asthma. We investigated whether in asthmatic patients with normal forced expiratory volume in the 1st second (FEV(1)) values, impulse oscillometry system (IOS), as a measure of small airway function, contributed additional information to spirometry either at baseline or after bronchodilator, and whether it was related to the disease control. The fall in resistance from 5 to 20 Hz (R5-R20) and reactance at 5 Hz (X5) by IOS and spirometry measures of small airway function (forced expiratory flow at 25-75% [FEF(25-75)] and forced vital capacity/slow inspiratory vital capacity [FVC/SVC]) at baseline and after 400 micrograms of salbutamol were prospectively measured in 33 asthmatic patients (18 women; age range, 18-66 years). Disease control was assessed by the Asthma Control Test (ACT). R5-R20 but not X5 values were significantly related to FEF(25-75) and FVC/SVC values (p < 0.05 for both correlations). When the bronchodilator response was assessed, no correlation was found among IOS and spirometry changes. ACT scores were related to R5-R20, FEF(25-75), and FVC/SVC values (p < 0.01 for all correlations). In asthmatic patients with normal FEV(1) values, R5-R20 values were related to spirometry measures of small airway function. However, when the bronchodilator response was assessed, IOS and spirometry provided quite different results. Moreover, small airway dysfunction, as assessed by IOS and spirometry, was associated with poor disease control and history of asthma exacerbations. The results of this study confirm the value of IOS, as an investigative tool, and suggest that in asthmatic patients with normal FEV(1) values and poor disease control, small airway function should be investigated. SN - 1539-6304 UR - https://www.unboundmedicine.com/medline/citation/23406931/Small_airway_dysfunction_by_impulse_oscillometry_in_asthmatic_patients_with_normal_forced_expiratory_volume_in_the_1st_second_values_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=1088-5412&amp;volume=34&amp;issue=1&amp;spage=e14&amp;aulast=Pisi DB - PRIME DP - Unbound Medicine ER -