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Cronkhite-Canada syndrome: a report of two familial cases.
Indian J Gastroenterol. 2013 Mar; 32(2):119-22.IJ

Abstract

Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. Since then, over 400 cases worldwide have been reported in the literature. The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain. An autoimmune etiology is suspected. The workup is based on history and physical examination, imaging, and endoscopy with biopsy to confirm gastrointestinal polyposis. Nutritional support and corticosteroids are the mainstay of treatment. Here, we describe two familial cases-one a 50-year-old male patient with chronic diarrhea and epigastric pain since 1.5 years with hyperpigmentation of the hand and foot, alopecia, anorexia, hypogeusia, and weight loss; other case was his 22-year-old son who was asymptomatic, with mild alopecia and hyperpigmentation over his face and hands. Gastrointestinal endoscopy showed multiple polyps in both the cases.

Authors+Show Affiliations

Department of General Surgery, B.L.D.E.U.'s Shri B. M. Patil Medical College and Research Centre, Bijapur 586 103, India. drvijayapatil@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23408256

Citation

Patil, Vijaya, et al. "Cronkhite-Canada Syndrome: a Report of Two Familial Cases." Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, vol. 32, no. 2, 2013, pp. 119-22.
Patil V, Patil LS, Jakareddy R, et al. Cronkhite-Canada syndrome: a report of two familial cases. Indian J Gastroenterol. 2013;32(2):119-22.
Patil, V., Patil, L. S., Jakareddy, R., Verma, A., & Gupta, A. B. (2013). Cronkhite-Canada syndrome: a report of two familial cases. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, 32(2), 119-22. https://doi.org/10.1007/s12664-012-0296-8
Patil V, et al. Cronkhite-Canada Syndrome: a Report of Two Familial Cases. Indian J Gastroenterol. 2013;32(2):119-22. PubMed PMID: 23408256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada syndrome: a report of two familial cases. AU - Patil,Vijaya, AU - Patil,Lingnagoud S, AU - Jakareddy,Rajeev, AU - Verma,Ashish, AU - Gupta,Amit B A, Y1 - 2013/02/14/ PY - 2012/06/15/received PY - 2012/12/24/accepted PY - 2013/2/15/entrez PY - 2013/2/15/pubmed PY - 2014/2/13/medline SP - 119 EP - 22 JF - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JO - Indian J Gastroenterol VL - 32 IS - 2 N2 - Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. Since then, over 400 cases worldwide have been reported in the literature. The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain. An autoimmune etiology is suspected. The workup is based on history and physical examination, imaging, and endoscopy with biopsy to confirm gastrointestinal polyposis. Nutritional support and corticosteroids are the mainstay of treatment. Here, we describe two familial cases-one a 50-year-old male patient with chronic diarrhea and epigastric pain since 1.5 years with hyperpigmentation of the hand and foot, alopecia, anorexia, hypogeusia, and weight loss; other case was his 22-year-old son who was asymptomatic, with mild alopecia and hyperpigmentation over his face and hands. Gastrointestinal endoscopy showed multiple polyps in both the cases. SN - 0975-0711 UR - https://www.unboundmedicine.com/medline/citation/23408256/Cronkhite_Canada_syndrome:_a_report_of_two_familial_cases_ L2 - https://dx.doi.org/10.1007/s12664-012-0296-8 DB - PRIME DP - Unbound Medicine ER -