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Absorption and urinary excretion of A-type procyanidin oligomers from Litchi chinensis pericarp in rats by selected ion monitoring liquid chromatography-mass spectrometry.
Food Chem. 2013 Jun 01; 138(2-3):1536-42.FC

Abstract

Intervention studies with A-type oligomeric procyanidins from litchi (Litchi chinensis) pericarp (LPOPC) suggested its protective effect against cardiovascular diseases. However, there is no consensus on the absorption and metabolism of LPOPC. It was demonstrated that the main components in LPOPC were (-)-epicatechin, A-type procyanidin dimers, trimers and tetramers. Rats were orally administered different levels of LPOPC (150 and 300 mg/kgbw), the procyanidins and their microbial metabolites in urine were identified by HPLC-MS/MS analysis 18 h post-administration. Data indicated that seven aromatic acid metabolites excreted were significantly increased by 300 mg/kgbw of LPOPC (P<0.01). However, only (-)-epicatechin and its methylated derivatives were detected in rat plasma 1h after 300 mg/kgbw of LPOPC administration. The total EC content absorbed in plasma was only 2.54 ± 0.53 μmol/L, indicating that the biological properties of LPOPC should be probably explained by its microbial degraded phenolic acids.

Authors+Show Affiliations

Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23411278

Citation

Li, Shuyi, et al. "Absorption and Urinary Excretion of A-type Procyanidin Oligomers From Litchi Chinensis Pericarp in Rats By Selected Ion Monitoring Liquid Chromatography-mass Spectrometry." Food Chemistry, vol. 138, no. 2-3, 2013, pp. 1536-42.
Li S, Sui Y, Xiao J, et al. Absorption and urinary excretion of A-type procyanidin oligomers from Litchi chinensis pericarp in rats by selected ion monitoring liquid chromatography-mass spectrometry. Food Chem. 2013;138(2-3):1536-42.
Li, S., Sui, Y., Xiao, J., Wu, Q., Hu, B., Xie, B., & Sun, Z. (2013). Absorption and urinary excretion of A-type procyanidin oligomers from Litchi chinensis pericarp in rats by selected ion monitoring liquid chromatography-mass spectrometry. Food Chemistry, 138(2-3), 1536-42. https://doi.org/10.1016/j.foodchem.2012.09.120
Li S, et al. Absorption and Urinary Excretion of A-type Procyanidin Oligomers From Litchi Chinensis Pericarp in Rats By Selected Ion Monitoring Liquid Chromatography-mass Spectrometry. Food Chem. 2013 Jun 1;138(2-3):1536-42. PubMed PMID: 23411278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absorption and urinary excretion of A-type procyanidin oligomers from Litchi chinensis pericarp in rats by selected ion monitoring liquid chromatography-mass spectrometry. AU - Li,Shuyi, AU - Sui,Yong, AU - Xiao,Juan, AU - Wu,Qian, AU - Hu,Bei, AU - Xie,Bijun, AU - Sun,Zhida, Y1 - 2012/11/08/ PY - 2012/06/21/received PY - 2012/08/17/revised PY - 2012/09/24/accepted PY - 2013/2/16/entrez PY - 2013/2/16/pubmed PY - 2013/8/21/medline SP - 1536 EP - 42 JF - Food chemistry JO - Food Chem VL - 138 IS - 2-3 N2 - Intervention studies with A-type oligomeric procyanidins from litchi (Litchi chinensis) pericarp (LPOPC) suggested its protective effect against cardiovascular diseases. However, there is no consensus on the absorption and metabolism of LPOPC. It was demonstrated that the main components in LPOPC were (-)-epicatechin, A-type procyanidin dimers, trimers and tetramers. Rats were orally administered different levels of LPOPC (150 and 300 mg/kgbw), the procyanidins and their microbial metabolites in urine were identified by HPLC-MS/MS analysis 18 h post-administration. Data indicated that seven aromatic acid metabolites excreted were significantly increased by 300 mg/kgbw of LPOPC (P<0.01). However, only (-)-epicatechin and its methylated derivatives were detected in rat plasma 1h after 300 mg/kgbw of LPOPC administration. The total EC content absorbed in plasma was only 2.54 ± 0.53 μmol/L, indicating that the biological properties of LPOPC should be probably explained by its microbial degraded phenolic acids. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/23411278/Absorption_and_urinary_excretion_of_A_type_procyanidin_oligomers_from_Litchi_chinensis_pericarp_in_rats_by_selected_ion_monitoring_liquid_chromatography_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(12)01581-6 DB - PRIME DP - Unbound Medicine ER -