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MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus.
Arch Oral Biol. 2013 Jul; 58(7):837-42.AO

Abstract

OBJECTIVE

Expression levels of MUC1 and TLR-2 were evaluated in burning mouth syndrome (BMS) patients and compared with those of controls and oral lichen planus (OLP) patients. The relationships between the expression levels of MUC1 and TLR-2 and levels of salivary pro-inflammatory cytokines were also investigated.

DESIGN

Ten female BMS and ten female OLP patients were included. Ten female age-matched volunteers served as controls. RNA was isolated from stimulated whole saliva samples. Real-time PCR was used to quantify MUC1 and TLR-2 mRNA levels relative to β-actin and GAPDH mRNA levels. The clarified supernatants of saliva samples were used to measure IL-1β, IL-6, IL-8, and TNF-α levels. The level of blood contamination in saliva samples was also determined.

RESULTS

There were significant increases in MUC1 transcripts in BMS patients compared with OLP patients (1.766-fold) as well as controls (1.840-fold). There was no significant difference in TLR-2 expression among the groups. The OLP patients showed significantly higher levels of IL-6 and blood contamination in saliva than other groups. The levels of MUC1 or TLR-2 expression did not correlate significantly with the levels of cytokines or blood contamination in saliva.

CONCLUSIONS

MUC1 may play a role in the development and/or progression of BMS.

Authors+Show Affiliations

Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul 110-749, Republic of Korea. hkho@snu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23411403

Citation

Kho, Hong-Seop, et al. "MUC1 and Toll-like Receptor-2 Expression in Burning Mouth Syndrome and Oral Lichen Planus." Archives of Oral Biology, vol. 58, no. 7, 2013, pp. 837-42.
Kho HS, Chang JY, Kim YY, et al. MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. Arch Oral Biol. 2013;58(7):837-42.
Kho, H. S., Chang, J. Y., Kim, Y. Y., & Kim, Y. (2013). MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. Archives of Oral Biology, 58(7), 837-42. https://doi.org/10.1016/j.archoralbio.2013.01.008
Kho HS, et al. MUC1 and Toll-like Receptor-2 Expression in Burning Mouth Syndrome and Oral Lichen Planus. Arch Oral Biol. 2013;58(7):837-42. PubMed PMID: 23411403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. AU - Kho,Hong-Seop, AU - Chang,Ji-Youn, AU - Kim,Yoon-Young, AU - Kim,Yongdae, Y1 - 2013/02/11/ PY - 2012/11/01/received PY - 2012/12/29/revised PY - 2013/01/15/accepted PY - 2013/2/16/entrez PY - 2013/2/16/pubmed PY - 2014/1/31/medline SP - 837 EP - 42 JF - Archives of oral biology JO - Arch Oral Biol VL - 58 IS - 7 N2 - OBJECTIVE: Expression levels of MUC1 and TLR-2 were evaluated in burning mouth syndrome (BMS) patients and compared with those of controls and oral lichen planus (OLP) patients. The relationships between the expression levels of MUC1 and TLR-2 and levels of salivary pro-inflammatory cytokines were also investigated. DESIGN: Ten female BMS and ten female OLP patients were included. Ten female age-matched volunteers served as controls. RNA was isolated from stimulated whole saliva samples. Real-time PCR was used to quantify MUC1 and TLR-2 mRNA levels relative to β-actin and GAPDH mRNA levels. The clarified supernatants of saliva samples were used to measure IL-1β, IL-6, IL-8, and TNF-α levels. The level of blood contamination in saliva samples was also determined. RESULTS: There were significant increases in MUC1 transcripts in BMS patients compared with OLP patients (1.766-fold) as well as controls (1.840-fold). There was no significant difference in TLR-2 expression among the groups. The OLP patients showed significantly higher levels of IL-6 and blood contamination in saliva than other groups. The levels of MUC1 or TLR-2 expression did not correlate significantly with the levels of cytokines or blood contamination in saliva. CONCLUSIONS: MUC1 may play a role in the development and/or progression of BMS. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/23411403/MUC1_and_Toll_like_receptor_2_expression_in_burning_mouth_syndrome_and_oral_lichen_planus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(13)00013-7 DB - PRIME DP - Unbound Medicine ER -