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Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type.
Neurochem Int. 2013 Mar; 62(4):492-501.NI

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive decline and enhancement of oxidative loads in the brain. Flavonoids have been considered to exert human health benefits by anti-oxidant and anti-inflammatory properties. The present study is aimed to elucidate the neuroprotective effect of catechin hydrate (CH), a natural flavanoid with potential antioxidant and anti-inflammatory properties, on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were pretreated with CH (10 and 20mg/kgb wt) orally once daily for 21 days and then bilaterally injected with ICV-STZ (3mg/kgb wt), while sham group rats receive the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using Morris water maze (MWM) test and then sacrifice for biochemical and histopathological assays. CH was found to be successful in upregulating the antioxidant status and prevented the memory loss. The expression of choline acetyl transferase (ChAT) was decreased in ICV-STZ group and CH pretreatment increases the expression of ChAT. Moreover, inflammatory mediators like TNF-α, IL-1β levels and expression of iNOS were significantly attenuated by CH pretreatment. The study suggests that CH is effective in preventing memory loss, ameliorating the oxidative stress and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).

Authors+Show Affiliations

Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology (Fund for the Improvement of Science and Technology Sponsored by DST and Special Assistance Programme Sponsored by UGC), Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23411413

Citation

Ejaz Ahmed, Md, et al. "Amelioration of Cognitive Impairment and Neurodegeneration By Catechin Hydrate in Rat Model of Streptozotocin-induced Experimental Dementia of Alzheimer's Type." Neurochemistry International, vol. 62, no. 4, 2013, pp. 492-501.
Ejaz Ahmed M, Khan MM, Javed H, et al. Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Neurochem Int. 2013;62(4):492-501.
Ejaz Ahmed, M., Khan, M. M., Javed, H., Vaibhav, K., Khan, A., Tabassum, R., Ashafaq, M., Islam, F., Safhi, M. M., & Islam, F. (2013). Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Neurochemistry International, 62(4), 492-501. https://doi.org/10.1016/j.neuint.2013.02.006
Ejaz Ahmed M, et al. Amelioration of Cognitive Impairment and Neurodegeneration By Catechin Hydrate in Rat Model of Streptozotocin-induced Experimental Dementia of Alzheimer's Type. Neurochem Int. 2013;62(4):492-501. PubMed PMID: 23411413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. AU - Ejaz Ahmed,Md, AU - Khan,Mohd Moshahid, AU - Javed,Hayate, AU - Vaibhav,Kumar, AU - Khan,Andleeb, AU - Tabassum,Rizwana, AU - Ashafaq,Mohammad, AU - Islam,Farah, AU - Safhi,Mohammed M, AU - Islam,Fakhrul, Y1 - 2013/02/11/ PY - 2012/09/09/received PY - 2013/01/26/revised PY - 2013/02/03/accepted PY - 2013/2/16/entrez PY - 2013/2/16/pubmed PY - 2013/9/21/medline SP - 492 EP - 501 JF - Neurochemistry international JO - Neurochem Int VL - 62 IS - 4 N2 - Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive decline and enhancement of oxidative loads in the brain. Flavonoids have been considered to exert human health benefits by anti-oxidant and anti-inflammatory properties. The present study is aimed to elucidate the neuroprotective effect of catechin hydrate (CH), a natural flavanoid with potential antioxidant and anti-inflammatory properties, on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were pretreated with CH (10 and 20mg/kgb wt) orally once daily for 21 days and then bilaterally injected with ICV-STZ (3mg/kgb wt), while sham group rats receive the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using Morris water maze (MWM) test and then sacrifice for biochemical and histopathological assays. CH was found to be successful in upregulating the antioxidant status and prevented the memory loss. The expression of choline acetyl transferase (ChAT) was decreased in ICV-STZ group and CH pretreatment increases the expression of ChAT. Moreover, inflammatory mediators like TNF-α, IL-1β levels and expression of iNOS were significantly attenuated by CH pretreatment. The study suggests that CH is effective in preventing memory loss, ameliorating the oxidative stress and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT). SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/23411413/Amelioration_of_cognitive_impairment_and_neurodegeneration_by_catechin_hydrate_in_rat_model_of_streptozotocin_induced_experimental_dementia_of_Alzheimer's_type_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(13)00045-4 DB - PRIME DP - Unbound Medicine ER -