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Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families.
Clin Genet 2013; 83(3):215-20CG

Abstract

The purpose of this study was to examine colonoscopy adherence and attitudes toward colorectal cancer (CRC) screening in individuals who underwent Lynch syndrome genetic counseling and testing. We evaluated changes in colonoscopy adherence and CRC screening attitudes in 78 cancer-unaffected relatives of Lynch syndrome mutation carriers before pre-test genetic counseling (baseline) and at 6 and 12 months post-disclosure of test results (52 mutation negative and 26 mutation positive). While both groups were similar at baseline, at 12 months post-disclosure, a greater number of mutation-positive individuals had had a colonoscopy compared with mutation-negative individuals. From baseline to 12 months post-disclosure, the mutation-positive group demonstrated an increase in mean scores on measures of colonoscopy commitment, self-efficacy, and perceived benefits of CRC screening, and a decrease in mean scores for perceived barriers to CRC screening. Mean scores on colonoscopy commitment decreased from baseline to 6 months in the mutation-negative group. To conclude, adherence to risk-appropriate guidelines for CRC surveillance improved after genetic counseling and testing for Lynch syndrome. Mutation-positive individuals reported increasingly positive attitudes toward CRC screening after receiving genetic test results, potentially reinforcing longer term colonoscopy adherence.

Authors+Show Affiliations

Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. aburton@mdanderson.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23414081

Citation

Burton-Chase, A M., et al. "Changes in Screening Behaviors and Attitudes Toward Screening From Pre-test Genetic Counseling to Post-disclosure in Lynch Syndrome Families." Clinical Genetics, vol. 83, no. 3, 2013, pp. 215-20.
Burton-Chase AM, Hovick SR, Peterson SK, et al. Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. Clin Genet. 2013;83(3):215-20.
Burton-Chase, A. M., Hovick, S. R., Peterson, S. K., Marani, S. K., Vernon, S. W., Amos, C. I., ... Gritz, E. R. (2013). Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. Clinical Genetics, 83(3), pp. 215-20. doi:10.1111/cge.12091.
Burton-Chase AM, et al. Changes in Screening Behaviors and Attitudes Toward Screening From Pre-test Genetic Counseling to Post-disclosure in Lynch Syndrome Families. Clin Genet. 2013;83(3):215-20. PubMed PMID: 23414081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. AU - Burton-Chase,A M, AU - Hovick,S R, AU - Peterson,S K, AU - Marani,S K, AU - Vernon,S W, AU - Amos,C I, AU - Frazier,M L, AU - Lynch,P M, AU - Gritz,E R, PY - 2012/10/30/received PY - 2013/01/03/revised PY - 2013/2/19/entrez PY - 2013/2/19/pubmed PY - 2013/8/28/medline SP - 215 EP - 20 JF - Clinical genetics JO - Clin. Genet. VL - 83 IS - 3 N2 - The purpose of this study was to examine colonoscopy adherence and attitudes toward colorectal cancer (CRC) screening in individuals who underwent Lynch syndrome genetic counseling and testing. We evaluated changes in colonoscopy adherence and CRC screening attitudes in 78 cancer-unaffected relatives of Lynch syndrome mutation carriers before pre-test genetic counseling (baseline) and at 6 and 12 months post-disclosure of test results (52 mutation negative and 26 mutation positive). While both groups were similar at baseline, at 12 months post-disclosure, a greater number of mutation-positive individuals had had a colonoscopy compared with mutation-negative individuals. From baseline to 12 months post-disclosure, the mutation-positive group demonstrated an increase in mean scores on measures of colonoscopy commitment, self-efficacy, and perceived benefits of CRC screening, and a decrease in mean scores for perceived barriers to CRC screening. Mean scores on colonoscopy commitment decreased from baseline to 6 months in the mutation-negative group. To conclude, adherence to risk-appropriate guidelines for CRC surveillance improved after genetic counseling and testing for Lynch syndrome. Mutation-positive individuals reported increasingly positive attitudes toward CRC screening after receiving genetic test results, potentially reinforcing longer term colonoscopy adherence. SN - 1399-0004 UR - https://www.unboundmedicine.com/medline/citation/23414081/Changes_in_screening_behaviors_and_attitudes_toward_screening_from_pre_test_genetic_counseling_to_post_disclosure_in_Lynch_syndrome_families_ L2 - https://doi.org/10.1111/cge.12091 DB - PRIME DP - Unbound Medicine ER -