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Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.
Allergy 2013; 68(4):549-52A

Abstract

Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α-Gal and tick bites. We provide the first direct evidence that α-Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to α-Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to α-Gal by the tick Ixodes ricinus is demonstrated. Furthermore, using cryostat-cut sections of I. ricinus, we show that both a monoclonal and a polyclonal antibody against α-Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to α-Gal. These results confirm that the α-Gal epitope is present in I. ricinus and imply host exposure to α-Gal during a tick bite. This provides further evidence that tick bites are associated with IgE responses to α-Gal and red meat allergy.

Authors+Show Affiliations

Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital Solna, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23414348

Citation

Hamsten, C, et al. "Identification of Galactose-α-1,3-galactose in the Gastrointestinal Tract of the Tick Ixodes Ricinus; Possible Relationship With Red Meat Allergy." Allergy, vol. 68, no. 4, 2013, pp. 549-52.
Hamsten C, Starkhammar M, Tran TA, et al. Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. Allergy. 2013;68(4):549-52.
Hamsten, C., Starkhammar, M., Tran, T. A., Johansson, M., Bengtsson, U., Ahlén, G., ... van Hage, M. (2013). Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. Allergy, 68(4), pp. 549-52. doi:10.1111/all.12128.
Hamsten C, et al. Identification of Galactose-α-1,3-galactose in the Gastrointestinal Tract of the Tick Ixodes Ricinus; Possible Relationship With Red Meat Allergy. Allergy. 2013;68(4):549-52. PubMed PMID: 23414348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. AU - Hamsten,C, AU - Starkhammar,M, AU - Tran,T A T, AU - Johansson,M, AU - Bengtsson,U, AU - Ahlén,G, AU - Sällberg,M, AU - Grönlund,H, AU - van Hage,M, Y1 - 2013/02/18/ PY - 2013/01/02/accepted PY - 2013/2/19/entrez PY - 2013/2/19/pubmed PY - 2013/9/7/medline SP - 549 EP - 52 JF - Allergy JO - Allergy VL - 68 IS - 4 N2 - Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α-Gal and tick bites. We provide the first direct evidence that α-Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to α-Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to α-Gal by the tick Ixodes ricinus is demonstrated. Furthermore, using cryostat-cut sections of I. ricinus, we show that both a monoclonal and a polyclonal antibody against α-Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to α-Gal. These results confirm that the α-Gal epitope is present in I. ricinus and imply host exposure to α-Gal during a tick bite. This provides further evidence that tick bites are associated with IgE responses to α-Gal and red meat allergy. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/23414348/Identification_of_galactose_α_13_galactose_in_the_gastrointestinal_tract_of_the_tick_Ixodes_ricinus L2 - https://doi.org/10.1111/all.12128 DB - PRIME DP - Unbound Medicine ER -