Tags

Type your tag names separated by a space and hit enter

Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis.
Nutrition 2013; 29(6):828-32N

Abstract

OBJECTIVE

Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with AD and PD. The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients.

METHODS

We searched all articles in English published up to March 2012 concerning the 25(OH)D level in AD and PD patients. For AD, six studies covering 319 patients and 573 controls were included in the meta-analysis. For PD, five studies discussing 434 patients and 3451 controls were included.

RESULTS

It was found that AD patients had lower levels of 25(OH)D than healthy controls (summary standardized mean difference [SMD], -1.39; 95% confidence interval [CI], -2.79 to 0.01). Similar results were found for PD patients versus healthy controls (summary SMD, -1.33; 95% CI, -2.44 to -0.21).

CONCLUSION

The results indicate that despite the similar mean age between patients and healthy controls in each identified study, both AD and PD patients have lower levels of 25(OH)D than controls.

Authors+Show Affiliations

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23415143

Citation

Zhao, Yan, et al. "Vitamin D Levels in Alzheimer's and Parkinson's Diseases: a Meta-analysis." Nutrition (Burbank, Los Angeles County, Calif.), vol. 29, no. 6, 2013, pp. 828-32.
Zhao Y, Sun Y, Ji HF, et al. Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis. Nutrition. 2013;29(6):828-32.
Zhao, Y., Sun, Y., Ji, H. F., & Shen, L. (2013). Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis. Nutrition (Burbank, Los Angeles County, Calif.), 29(6), pp. 828-32. doi:10.1016/j.nut.2012.11.018.
Zhao Y, et al. Vitamin D Levels in Alzheimer's and Parkinson's Diseases: a Meta-analysis. Nutrition. 2013;29(6):828-32. PubMed PMID: 23415143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis. AU - Zhao,Yan, AU - Sun,Yan, AU - Ji,Hong-Fang, AU - Shen,Liang, Y1 - 2013/02/13/ PY - 2012/07/06/received PY - 2012/11/25/revised PY - 2012/11/25/accepted PY - 2013/2/19/entrez PY - 2013/2/19/pubmed PY - 2014/1/17/medline SP - 828 EP - 32 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 29 IS - 6 N2 - OBJECTIVE: Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with AD and PD. The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients. METHODS: We searched all articles in English published up to March 2012 concerning the 25(OH)D level in AD and PD patients. For AD, six studies covering 319 patients and 573 controls were included in the meta-analysis. For PD, five studies discussing 434 patients and 3451 controls were included. RESULTS: It was found that AD patients had lower levels of 25(OH)D than healthy controls (summary standardized mean difference [SMD], -1.39; 95% confidence interval [CI], -2.79 to 0.01). Similar results were found for PD patients versus healthy controls (summary SMD, -1.33; 95% CI, -2.44 to -0.21). CONCLUSION: The results indicate that despite the similar mean age between patients and healthy controls in each identified study, both AD and PD patients have lower levels of 25(OH)D than controls. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/23415143/Vitamin_D_levels_in_Alzheimer's_and_Parkinson's_diseases:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(12)00465-0 DB - PRIME DP - Unbound Medicine ER -