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Effectiveness of pulmonary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and without global fat-free mass depletion.
Arch Phys Med Rehabil. 2013 Aug; 94(8):1607-14.AP

Abstract

OBJECTIVE

To investigate the effectiveness of pulmonary rehabilitation (PR) in exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD) with and without global fat-free mass (FFM) depletion.

DESIGN

Retrospective case-control.

SETTING

Outpatient clinic, university center.

PARTICIPANTS

COPD patients (N=102) that completed PR were initially evaluated.

INTERVENTION

PR including whole-body and weight training for 12 weeks, 3 times per week.

MAIN OUTCOME MEASURES

St. George Respiratory Questionnaire (SGRQ), 6-minute walk distance (6MWD), and FFM evaluation applied before and after PR.

RESULTS

Patients were stratified according to their FFM status measured by bioelectric impedance. They were considered depleted if the FFM index was ≤ 15 kg/m(2) in women and ≤ 16 kg/m(2) in men. From the initial sample, all depleted patients (n=31) composed the FFM depleted group. It was composed predominantly by women (68%) with a mean age ± SD of 64.4 ± 7.3 years and a forced expiratory volume in 1 second of 33.6%=-13.2% predicted. Paired for sex and age, 31 nondepleted patients were selected from the initial sample to compose the nondepleted group. Improvement in the 6MWD was similar in these 2 groups after PR. Both groups improved SGRQ scores, although the observed power was small and did not allow adequate comparison between depleted and nondepleted patients. There was no difference between groups in weight change, whereas FFM tended to be greater in depleted patients. This increase had no correlation with the 6MWD or the SGRQ.

CONCLUSIONS

Benefits of PR to exercise capacity were similar comparing FFM depleted and nondepleted COPD patients. Although FFM change tended to be greater in depleted patients, this increase had no definite relation with clinical outcomes.

Authors+Show Affiliations

Post-Graduate Program in Sciences (Pulmonology), Federal University of Rio Grande do Sul, Porto Alegre, Brazil. dcberton@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23416765

Citation

Berton, Danilo C., et al. "Effectiveness of Pulmonary Rehabilitation in Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease Patients With and Without Global Fat-free Mass Depletion." Archives of Physical Medicine and Rehabilitation, vol. 94, no. 8, 2013, pp. 1607-14.
Berton DC, Silveira L, Da Costa CC, et al. Effectiveness of pulmonary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and without global fat-free mass depletion. Arch Phys Med Rehabil. 2013;94(8):1607-14.
Berton, D. C., Silveira, L., Da Costa, C. C., De Souza, R. M., Winter, C. D., & Zimermann Teixeira, P. J. (2013). Effectiveness of pulmonary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and without global fat-free mass depletion. Archives of Physical Medicine and Rehabilitation, 94(8), 1607-14. https://doi.org/10.1016/j.apmr.2013.02.005
Berton DC, et al. Effectiveness of Pulmonary Rehabilitation in Exercise Capacity and Quality of Life in Chronic Obstructive Pulmonary Disease Patients With and Without Global Fat-free Mass Depletion. Arch Phys Med Rehabil. 2013;94(8):1607-14. PubMed PMID: 23416765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of pulmonary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and without global fat-free mass depletion. AU - Berton,Danilo C, AU - Silveira,Leonardo, AU - Da Costa,Cassia C, AU - De Souza,Rafael Machado, AU - Winter,Claudia D, AU - Zimermann Teixeira,Paulo José, Y1 - 2013/02/14/ PY - 2012/08/03/received PY - 2013/01/24/revised PY - 2013/02/04/accepted PY - 2013/2/19/entrez PY - 2013/2/19/pubmed PY - 2013/11/1/medline KW - 6-minute walk distance KW - 6MWD KW - BMI KW - COPD KW - Exercise KW - FEV(1) KW - FFM KW - FVC KW - HRQOL KW - MANOVA KW - MRC KW - Medical Research Council KW - Muscles KW - PR KW - Pulmonary disease KW - RM KW - Rehabilitation KW - SGRQ KW - St. George Respiratory Questionnaire KW - body mass index KW - chronic obstructive KW - chronic obstructive pulmonary disease KW - fat-free mass KW - forced expiratory volume in 1 second KW - forced vital capacity KW - health-related quality of life KW - multiple analysis of variance KW - pulmonary rehabilitation KW - repetition maximum SP - 1607 EP - 14 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 94 IS - 8 N2 - OBJECTIVE: To investigate the effectiveness of pulmonary rehabilitation (PR) in exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD) with and without global fat-free mass (FFM) depletion. DESIGN: Retrospective case-control. SETTING: Outpatient clinic, university center. PARTICIPANTS: COPD patients (N=102) that completed PR were initially evaluated. INTERVENTION: PR including whole-body and weight training for 12 weeks, 3 times per week. MAIN OUTCOME MEASURES: St. George Respiratory Questionnaire (SGRQ), 6-minute walk distance (6MWD), and FFM evaluation applied before and after PR. RESULTS: Patients were stratified according to their FFM status measured by bioelectric impedance. They were considered depleted if the FFM index was ≤ 15 kg/m(2) in women and ≤ 16 kg/m(2) in men. From the initial sample, all depleted patients (n=31) composed the FFM depleted group. It was composed predominantly by women (68%) with a mean age ± SD of 64.4 ± 7.3 years and a forced expiratory volume in 1 second of 33.6%=-13.2% predicted. Paired for sex and age, 31 nondepleted patients were selected from the initial sample to compose the nondepleted group. Improvement in the 6MWD was similar in these 2 groups after PR. Both groups improved SGRQ scores, although the observed power was small and did not allow adequate comparison between depleted and nondepleted patients. There was no difference between groups in weight change, whereas FFM tended to be greater in depleted patients. This increase had no correlation with the 6MWD or the SGRQ. CONCLUSIONS: Benefits of PR to exercise capacity were similar comparing FFM depleted and nondepleted COPD patients. Although FFM change tended to be greater in depleted patients, this increase had no definite relation with clinical outcomes. SN - 1532-821X UR - https://www.unboundmedicine.com/medline/citation/23416765/Effectiveness_of_pulmonary_rehabilitation_in_exercise_capacity_and_quality_of_life_in_chronic_obstructive_pulmonary_disease_patients_with_and_without_global_fat_free_mass_depletion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(13)00129-9 DB - PRIME DP - Unbound Medicine ER -