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An independent components and functional connectivity analysis of resting state fMRI data points to neural network dysregulation in adult ADHD.
Hum Brain Mapp. 2014 Apr; 35(4):1261-72.HB

Abstract

Spontaneous fluctuations can be measured in the brain that reflect dissociable functional networks oscillating at synchronized frequencies, such as the default mode network (DMN). In contrast to its diametrically opposed task-positive counterpart, the DMN predominantly signals during a state of rest, and inappropriate regulation of this network has been associated with inattention, a core characteristic of attention-deficit/hyperactivity disorder (ADHD). To examine whether abnormalities can be identified in the DMN component of patients with ADHD, we applied an independent components analysis to resting state functional magnetic resonance imaging data acquired from 22 male medication-naïve adults with ADHD and 23 neurotypical individuals. We observed a stronger coherence of the left dorsolateral prefrontal cortex (dlPFC) with the DMN component in patients with ADHD which correlated with measures of selective attention. The increased left dlPFC-DMN coherence also surfaced in a whole-brain replication analysis involving an independent sample of 9 medication-naïve adult patients and 9 controls. In addition, a post hoc seed-to-voxel functional connectivity analysis using the dlPFC as a seed region to further examine this region's suggested connectivity differences uncovered a higher temporal coherence with various other neural networks and confirmed a reduced anticorrelation with the DMN. These results point to a more diffuse connectivity between functional networks in patients with ADHD. Moreover, our findings suggest that state-inappropriate neural activity in ADHD is not confined to DMN intrusion during attention-demanding contexts, but also surfaces as an insufficient suppression of dlPFC signaling in relation to DMN activity during rest. Together with previous findings, these results point to a general dysfunction in the orthogonality of functional networks.

Authors+Show Affiliations

Unitat de Recerca en Neurociència Cognitiva, Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain; Grup de Recerca en Neuroimatge, Fundació IMIM, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23417778

Citation

Hoekzema, Elseline, et al. "An Independent Components and Functional Connectivity Analysis of Resting State fMRI Data Points to Neural Network Dysregulation in Adult ADHD." Human Brain Mapping, vol. 35, no. 4, 2014, pp. 1261-72.
Hoekzema E, Carmona S, Ramos-Quiroga JA, et al. An independent components and functional connectivity analysis of resting state fMRI data points to neural network dysregulation in adult ADHD. Hum Brain Mapp. 2014;35(4):1261-72.
Hoekzema, E., Carmona, S., Ramos-Quiroga, J. A., Richarte Fernández, V., Bosch, R., Soliva, J. C., Rovira, M., Bulbena, A., Tobeña, A., Casas, M., & Vilarroya, O. (2014). An independent components and functional connectivity analysis of resting state fMRI data points to neural network dysregulation in adult ADHD. Human Brain Mapping, 35(4), 1261-72. https://doi.org/10.1002/hbm.22250
Hoekzema E, et al. An Independent Components and Functional Connectivity Analysis of Resting State fMRI Data Points to Neural Network Dysregulation in Adult ADHD. Hum Brain Mapp. 2014;35(4):1261-72. PubMed PMID: 23417778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An independent components and functional connectivity analysis of resting state fMRI data points to neural network dysregulation in adult ADHD. AU - Hoekzema,Elseline, AU - Carmona,Susana, AU - Ramos-Quiroga,J Antoni, AU - Richarte Fernández,Vanesa, AU - Bosch,Rosa, AU - Soliva,Juan Carlos, AU - Rovira,Mariana, AU - Bulbena,Antonio, AU - Tobeña,Adolf, AU - Casas,Miguel, AU - Vilarroya,Oscar, Y1 - 2013/02/18/ PY - 2012/06/22/received PY - 2012/10/01/revised PY - 2012/12/03/accepted PY - 2013/2/19/entrez PY - 2013/2/19/pubmed PY - 2014/12/15/medline KW - attention-deficit/hyperactivity disorder KW - default mode network KW - dorsolateral prefrontal cortex KW - functional magnetic resonance imaging KW - independent components analysis KW - rest SP - 1261 EP - 72 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 4 N2 - Spontaneous fluctuations can be measured in the brain that reflect dissociable functional networks oscillating at synchronized frequencies, such as the default mode network (DMN). In contrast to its diametrically opposed task-positive counterpart, the DMN predominantly signals during a state of rest, and inappropriate regulation of this network has been associated with inattention, a core characteristic of attention-deficit/hyperactivity disorder (ADHD). To examine whether abnormalities can be identified in the DMN component of patients with ADHD, we applied an independent components analysis to resting state functional magnetic resonance imaging data acquired from 22 male medication-naïve adults with ADHD and 23 neurotypical individuals. We observed a stronger coherence of the left dorsolateral prefrontal cortex (dlPFC) with the DMN component in patients with ADHD which correlated with measures of selective attention. The increased left dlPFC-DMN coherence also surfaced in a whole-brain replication analysis involving an independent sample of 9 medication-naïve adult patients and 9 controls. In addition, a post hoc seed-to-voxel functional connectivity analysis using the dlPFC as a seed region to further examine this region's suggested connectivity differences uncovered a higher temporal coherence with various other neural networks and confirmed a reduced anticorrelation with the DMN. These results point to a more diffuse connectivity between functional networks in patients with ADHD. Moreover, our findings suggest that state-inappropriate neural activity in ADHD is not confined to DMN intrusion during attention-demanding contexts, but also surfaces as an insufficient suppression of dlPFC signaling in relation to DMN activity during rest. Together with previous findings, these results point to a general dysfunction in the orthogonality of functional networks. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/23417778/An_independent_components_and_functional_connectivity_analysis_of_resting_state_fMRI_data_points_to_neural_network_dysregulation_in_adult_ADHD_ L2 - https://doi.org/10.1002/hbm.22250 DB - PRIME DP - Unbound Medicine ER -