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Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study.
J Lipid Res. 1990 Mar; 31(3):487-95.JL

Abstract

Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease (CHD) risk. We determined the apoE phenotypes and plasma lipid levels in 1577 youths aged 3 to 18 years in 1980. The subjects were randomly selected from five areas of Finland. ApoE phenotyping was performed directly from plasma by isoelectric focusing and immunoblotting. The apoE allele frequencies in the population sample were epsilon 2 = 0.039, epsilon 3 = 0.767, and epsilon 4 = 0.194. There were no differences in the apoE phenotype distribution between East and West Finland or between sexes. The concentrations of serum total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B increased with apoE phenotype in the order of E2/2, E3/2, E4/2, E3/3, E4/3, and E4/4. This increase was already seen in 3-year-old children; it was observed in both sexes, but was clearer in males than in females. The mean levels of high density lipoprotein (HDL) cholesterol, apolipoprotein A-I, triglyceride, Lp[a] lipoprotein, and the activity of lecithin:cholesterol acyltransferase did not differ between the apoE phenotypes. The observed differences in serum cholesterol remained fairly stable during the 6-year follow-up from 1980 to 1986, while the mean serum cholesterol concentration in the whole study population decreased by 6.3%. This study confirms the reported higher frequency of the epsilon 4 allele in Finns as compared to most other populations; this may contribute to the high rates of CHD in Finland as compared to most other populations. The results do not, however, explain the higher rate of CHD in East Finland in comparison to the western part of the country.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2341810

Citation

Lehtimäki, T, et al. "Apolipoprotein E Phenotypes in Finnish Youths: a Cross-sectional and 6-year Follow-up Study." Journal of Lipid Research, vol. 31, no. 3, 1990, pp. 487-95.
Lehtimäki T, Moilanen T, Viikari J, et al. Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. J Lipid Res. 1990;31(3):487-95.
Lehtimäki, T., Moilanen, T., Viikari, J., Akerblom, H. K., Ehnholm, C., Rönnemaa, T., Marniemi, J., Dahlen, G., & Nikkari, T. (1990). Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. Journal of Lipid Research, 31(3), 487-95.
Lehtimäki T, et al. Apolipoprotein E Phenotypes in Finnish Youths: a Cross-sectional and 6-year Follow-up Study. J Lipid Res. 1990;31(3):487-95. PubMed PMID: 2341810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. AU - Lehtimäki,T, AU - Moilanen,T, AU - Viikari,J, AU - Akerblom,H K, AU - Ehnholm,C, AU - Rönnemaa,T, AU - Marniemi,J, AU - Dahlen,G, AU - Nikkari,T, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 487 EP - 95 JF - Journal of lipid research JO - J. Lipid Res. VL - 31 IS - 3 N2 - Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease (CHD) risk. We determined the apoE phenotypes and plasma lipid levels in 1577 youths aged 3 to 18 years in 1980. The subjects were randomly selected from five areas of Finland. ApoE phenotyping was performed directly from plasma by isoelectric focusing and immunoblotting. The apoE allele frequencies in the population sample were epsilon 2 = 0.039, epsilon 3 = 0.767, and epsilon 4 = 0.194. There were no differences in the apoE phenotype distribution between East and West Finland or between sexes. The concentrations of serum total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B increased with apoE phenotype in the order of E2/2, E3/2, E4/2, E3/3, E4/3, and E4/4. This increase was already seen in 3-year-old children; it was observed in both sexes, but was clearer in males than in females. The mean levels of high density lipoprotein (HDL) cholesterol, apolipoprotein A-I, triglyceride, Lp[a] lipoprotein, and the activity of lecithin:cholesterol acyltransferase did not differ between the apoE phenotypes. The observed differences in serum cholesterol remained fairly stable during the 6-year follow-up from 1980 to 1986, while the mean serum cholesterol concentration in the whole study population decreased by 6.3%. This study confirms the reported higher frequency of the epsilon 4 allele in Finns as compared to most other populations; this may contribute to the high rates of CHD in Finland as compared to most other populations. The results do not, however, explain the higher rate of CHD in East Finland in comparison to the western part of the country. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/2341810/Apolipoprotein_E_phenotypes_in_Finnish_youths:_a_cross_sectional_and_6_year_follow_up_study_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=2341810 DB - PRIME DP - Unbound Medicine ER -