Tags

Type your tag names separated by a space and hit enter

Preparation and characterization of progesterone dispersions using supercritical carbon dioxide.
Drug Dev Ind Pharm. 2014 Apr; 40(4):458-69.DD

Abstract

CONTEXT

Supercritical fluid methods offer an alternative to conventional mixing methods, particularly for heat sensitive drugs and where an organic solvent is undesirable.

OBJECTIVE

To design, develop and construct a unit for the particles from a gas-saturated suspension/solution (PGSS) method and form endogenous progesterone (PGN) dispersion systems using SC-CO2.

MATERIALS AND METHODS

The PGN dispersions were manufactured using three selected excipients: polyethylene glycol (PEG) 400/4000 (50:50), Gelucire 44/14 and D-α-tocopheryl PEG 1000 succinate (TPGS). Semisolid dispersions of PGN prepared by PGSS method were compared to the conventional methods; comelting (CM), cosolvent (CS) and physical mixing (PM). The dispersion systems made were characterized by Raman and Fourier transform infrared (FTIR) spectroscopies, X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), PGN recovery, uniformity and in vitro dissolution, analyzed by high-performance liquid chromatography (HPLC).

RESULTS

Raman spectra revealed no changes in the crystalline structure of PGN treated with SC-CO2 compared to that of untreated PGN. XRPD and FTIR showed the presence of peaks and bands for PGN confirming that PGN has been incorporated well with each individual excipient. All PGN dispersions prepared by the PGSS method resulted in the improvement of PGN dissolution rates compared to that prepared by the conventional methods and untreated PGN after 60 min (p value < 0.05).

CONCLUSION

The novel PGN dispersions prepared by the PGSS method offer the great potential to enhance PGN dissolution rate, reduce preparation time and form stable crystalline dispersion systems over those prepared by conventional methods.

Authors+Show Affiliations

Drug Delivery Research Unit (2DRU), School of Pharmacy, Faculty of Medical and Health Sciences and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23418960

Citation

Falconer, James R., et al. "Preparation and Characterization of Progesterone Dispersions Using Supercritical Carbon Dioxide." Drug Development and Industrial Pharmacy, vol. 40, no. 4, 2014, pp. 458-69.
Falconer JR, Wen J, Zargar-Shoshtari S, et al. Preparation and characterization of progesterone dispersions using supercritical carbon dioxide. Drug Dev Ind Pharm. 2014;40(4):458-69.
Falconer, J. R., Wen, J., Zargar-Shoshtari, S., Chen, J. J., Farid, M., Tallon, S. J., & Alany, R. G. (2014). Preparation and characterization of progesterone dispersions using supercritical carbon dioxide. Drug Development and Industrial Pharmacy, 40(4), 458-69. https://doi.org/10.3109/03639045.2013.768630
Falconer JR, et al. Preparation and Characterization of Progesterone Dispersions Using Supercritical Carbon Dioxide. Drug Dev Ind Pharm. 2014;40(4):458-69. PubMed PMID: 23418960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of progesterone dispersions using supercritical carbon dioxide. AU - Falconer,James R, AU - Wen,Jingyuan, AU - Zargar-Shoshtari,Sara, AU - Chen,John J, AU - Farid,Mohammed, AU - Tallon,Stephen J, AU - Alany,Raid G, Y1 - 2013/02/18/ PY - 2013/2/20/entrez PY - 2013/2/20/pubmed PY - 2014/11/5/medline SP - 458 EP - 69 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 40 IS - 4 N2 - CONTEXT: Supercritical fluid methods offer an alternative to conventional mixing methods, particularly for heat sensitive drugs and where an organic solvent is undesirable. OBJECTIVE: To design, develop and construct a unit for the particles from a gas-saturated suspension/solution (PGSS) method and form endogenous progesterone (PGN) dispersion systems using SC-CO2. MATERIALS AND METHODS: The PGN dispersions were manufactured using three selected excipients: polyethylene glycol (PEG) 400/4000 (50:50), Gelucire 44/14 and D-α-tocopheryl PEG 1000 succinate (TPGS). Semisolid dispersions of PGN prepared by PGSS method were compared to the conventional methods; comelting (CM), cosolvent (CS) and physical mixing (PM). The dispersion systems made were characterized by Raman and Fourier transform infrared (FTIR) spectroscopies, X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), PGN recovery, uniformity and in vitro dissolution, analyzed by high-performance liquid chromatography (HPLC). RESULTS: Raman spectra revealed no changes in the crystalline structure of PGN treated with SC-CO2 compared to that of untreated PGN. XRPD and FTIR showed the presence of peaks and bands for PGN confirming that PGN has been incorporated well with each individual excipient. All PGN dispersions prepared by the PGSS method resulted in the improvement of PGN dissolution rates compared to that prepared by the conventional methods and untreated PGN after 60 min (p value < 0.05). CONCLUSION: The novel PGN dispersions prepared by the PGSS method offer the great potential to enhance PGN dissolution rate, reduce preparation time and form stable crystalline dispersion systems over those prepared by conventional methods. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/23418960/Preparation_and_characterization_of_progesterone_dispersions_using_supercritical_carbon_dioxide_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2013.768630 DB - PRIME DP - Unbound Medicine ER -