Tags

Type your tag names separated by a space and hit enter

Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007-2009).
Int J Hyg Environ Health. 2013 Nov; 216(6):652-61.IJ

Abstract

Human exposure to phthalates occurs through multiple sources and pathways. In the Canadian Health Measures Survey 2007-2009, 11 phthalate metabolites, namely, MMP, MEP, MnBP, MBzP, MCHP, MCPP, MEHP, MEOHP, MEHHP, MnOP, and MiNP were measured in urine samples of 6-49 year old survey respondents (n=3236). The phthalate metabolites biomonitoring data from this nationally-representative Canadian survey are presented here. The metabolites MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP were detected in >90% of Canadians while MMP, MCHP, MnOP and MiNP were detected in <20% of the Canadian population. Step-wise regression analyses were carried out to identify important predictors of volumetric concentrations (μg/L) of the metabolites in the general population. Individual multiple regression models with covariates age, sex, creatinine, fasting status, and the interaction terms age×creatinine, age×sex and fasting status×creatinine were constructed for MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP. The least square geometric mean (LSGM) estimates for volumetric concentration (μg/L) of the metabolites derived from respective regression models were used to assess the patterns in the metabolite concentrations among population sub-groups. The results indicate that children had significantly higher urinary concentrations of MnBP, MBzP, MEHP, MEHHP, MEOHP and MCPP than adolescents and adults. Moreover, MEP, MBzP, MnBP and MEOHP concentrations in females were significantly higher than in males. We observed that fasting status significantly affects the concentrations of MEHP, MEHHP, MEOHP, and MCPP metabolites analyzed in this study. Moreover, our results indicate that the sampling time could affect the DEHP metabolite concentrations in the general Canadian population.

Authors+Show Affiliations

Chemicals Surveillance Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Canada. Electronic address: gurusankar.saravanabhavan@hc-sc.gc.ca.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23419587

Citation

Saravanabhavan, Gurusankar, et al. "Biomonitoring of Phthalate Metabolites in the Canadian Population Through the Canadian Health Measures Survey (2007-2009)." International Journal of Hygiene and Environmental Health, vol. 216, no. 6, 2013, pp. 652-61.
Saravanabhavan G, Guay M, Langlois É, et al. Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007-2009). Int J Hyg Environ Health. 2013;216(6):652-61.
Saravanabhavan, G., Guay, M., Langlois, É., Giroux, S., Murray, J., & Haines, D. (2013). Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007-2009). International Journal of Hygiene and Environmental Health, 216(6), 652-61. https://doi.org/10.1016/j.ijheh.2012.12.009
Saravanabhavan G, et al. Biomonitoring of Phthalate Metabolites in the Canadian Population Through the Canadian Health Measures Survey (2007-2009). Int J Hyg Environ Health. 2013;216(6):652-61. PubMed PMID: 23419587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007-2009). AU - Saravanabhavan,Gurusankar, AU - Guay,Mireille, AU - Langlois,Éric, AU - Giroux,Suzelle, AU - Murray,Janine, AU - Haines,Douglas, Y1 - 2013/02/16/ PY - 2012/07/12/received PY - 2012/12/07/revised PY - 2012/12/11/accepted PY - 2013/2/20/entrez PY - 2013/2/20/pubmed PY - 2014/4/9/medline KW - BBzP KW - Canadian Health Measures Survey KW - Canadian population KW - Chemical surveillance KW - DCHP KW - DEHA KW - DEHP KW - DEP KW - DMP KW - DiNCH KW - DiNP KW - DnBP KW - DnOP KW - Human biomonitoring KW - MBzP KW - MCHP KW - MCPP KW - MEHHP KW - MEHP KW - MEOHP KW - MEP KW - MMP KW - MiBP KW - MiDP KW - MiNP KW - MnBP KW - MnOP KW - PVC KW - Phthalates KW - TETM KW - UPLC–MS–MS KW - Urinary metabolites KW - butyl benzyl phthalate KW - di(2-ethylhexyl) phthalate KW - di(ethylhexyl) adipate KW - di(isononyl) phthalate KW - di(isononyl)cyclohexane-1,2-dicarboxylate KW - di(n-butyl) phthalate KW - di(n-octyl) phthalate KW - dicyclohexyl phthalate KW - diethyl phthalate KW - dimethyl phthalate KW - mono-(2-ethyl-5-hydroxyhexyl) phthalate KW - mono-(2-ethyl-5-oxohexyl) phthalate KW - mono-2-ethylhexyl phthalate KW - mono-3-carboxylpropyl phthalate KW - mono-iso-butyl phthalate KW - mono-n-butyl phthalate KW - mono-n-octyl phthalate KW - monobenzyl phthalate KW - monocyclohexyl phthalate KW - monoethyl phthalate KW - monoisodecyl phthalate KW - monoisononyl phthalate KW - monomethyl phthalate KW - polyvinyl chloride KW - tri (2-ethylhexyl) trimellitate KW - ultrahigh pressure liquid chromatography–tandem mass spectrometry SP - 652 EP - 61 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 216 IS - 6 N2 - Human exposure to phthalates occurs through multiple sources and pathways. In the Canadian Health Measures Survey 2007-2009, 11 phthalate metabolites, namely, MMP, MEP, MnBP, MBzP, MCHP, MCPP, MEHP, MEOHP, MEHHP, MnOP, and MiNP were measured in urine samples of 6-49 year old survey respondents (n=3236). The phthalate metabolites biomonitoring data from this nationally-representative Canadian survey are presented here. The metabolites MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP were detected in >90% of Canadians while MMP, MCHP, MnOP and MiNP were detected in <20% of the Canadian population. Step-wise regression analyses were carried out to identify important predictors of volumetric concentrations (μg/L) of the metabolites in the general population. Individual multiple regression models with covariates age, sex, creatinine, fasting status, and the interaction terms age×creatinine, age×sex and fasting status×creatinine were constructed for MEP, MnBP, MBzP, MCPP, MEHP, MEOHP and MEHHP. The least square geometric mean (LSGM) estimates for volumetric concentration (μg/L) of the metabolites derived from respective regression models were used to assess the patterns in the metabolite concentrations among population sub-groups. The results indicate that children had significantly higher urinary concentrations of MnBP, MBzP, MEHP, MEHHP, MEOHP and MCPP than adolescents and adults. Moreover, MEP, MBzP, MnBP and MEOHP concentrations in females were significantly higher than in males. We observed that fasting status significantly affects the concentrations of MEHP, MEHHP, MEOHP, and MCPP metabolites analyzed in this study. Moreover, our results indicate that the sampling time could affect the DEHP metabolite concentrations in the general Canadian population. SN - 1618-131X UR - https://www.unboundmedicine.com/medline/citation/23419587/Biomonitoring_of_phthalate_metabolites_in_the_Canadian_population_through_the_Canadian_Health_Measures_Survey__2007_2009__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(12)00145-9 DB - PRIME DP - Unbound Medicine ER -