Tags

Type your tag names separated by a space and hit enter

Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers.
Nutr Metab Cardiovasc Dis. 2013 Dec; 23(12):1182-7.NM

Abstract

BACKGROUND AND AIMS

Nonalcoholic fatty liver disease (NAFLD) is linked with insulin resistance, however, if it is differentially associated with surrogate hepatic insulin resistance indexes is still undefined. We examined the relationship between these indexes, NAFLD and its related biomarkers (alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma-glutamyltransferase [GGT], alkaline phosphatase [ALK], high-sensitive C reactive protein [hsCRP], insulin-like growth factor-1 [IGF-1]).

METHODS AND RESULTS

473 Caucasians subjects underwent liver ultrasonography and oral glucose tolerance tests; homeostasis model assessment (HOMA), glucose(0-30) (area under the curve [AUC]) × insulin(0-30) (AUC) and liver insulin resistance (liver IR) indexes were computed. Liver IR index correlated more strongly than HOMA with GGT, ALK, hsCRP, ALT and AST and more strongly than glucose(0-30) (AUC) × insulin(0-30) (AUC) index with ALT, AST, GGT, ALK, hsCRP, and IGF-1. The ability of these indexes to identify NAFLD was evaluated by the area under the ROC curve; the ROC AUC for liver IR index was higher (0.733) than the ones for HOMA (0.685) and glucose(0-30) (AUC) × insulin(0-30) (AUC) (0.663) indexes. In a logistic regression model subjects in the highest quartile of the three indexes had a higher risk of having NAFLD than those in the lowest quartile (9.85-, 5.12- or 3.99-fold higher for liver IR index, HOMA, glucose(0-30) (AUC) × insulin(0-30) (AUC) index respectively).

CONCLUSIONS

we documented significant cross-sectional associations of NAFLD and liver biomarkers with three validated indexes of hepatic insulin resistance, with liver IR index showing the stronger correlation.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Viale Europa, Catanzaro 88100, Italy. Electronic address: sesti@unicz.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23419734

Citation

Sesti, G, et al. "Association of Hepatic Insulin Resistance Indexes to Nonalcoholic Fatty Liver Disease and Related Biomarkers." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 12, 2013, pp. 1182-7.
Sesti G, Fiorentino TV, Hribal ML, et al. Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers. Nutr Metab Cardiovasc Dis. 2013;23(12):1182-7.
Sesti, G., Fiorentino, T. V., Hribal, M. L., Sciacqua, A., & Perticone, F. (2013). Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(12), 1182-7. https://doi.org/10.1016/j.numecd.2013.01.006
Sesti G, et al. Association of Hepatic Insulin Resistance Indexes to Nonalcoholic Fatty Liver Disease and Related Biomarkers. Nutr Metab Cardiovasc Dis. 2013;23(12):1182-7. PubMed PMID: 23419734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers. AU - Sesti,G, AU - Fiorentino,T V, AU - Hribal,M L, AU - Sciacqua,A, AU - Perticone,F, Y1 - 2013/02/15/ PY - 2012/09/18/received PY - 2012/12/27/revised PY - 2013/01/12/accepted PY - 2013/2/20/entrez PY - 2013/2/20/pubmed PY - 2014/7/30/medline KW - Hepatic insulin resistance indexes KW - Liver biomarkers KW - NAFLD SP - 1182 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 12 N2 - BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is linked with insulin resistance, however, if it is differentially associated with surrogate hepatic insulin resistance indexes is still undefined. We examined the relationship between these indexes, NAFLD and its related biomarkers (alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma-glutamyltransferase [GGT], alkaline phosphatase [ALK], high-sensitive C reactive protein [hsCRP], insulin-like growth factor-1 [IGF-1]). METHODS AND RESULTS: 473 Caucasians subjects underwent liver ultrasonography and oral glucose tolerance tests; homeostasis model assessment (HOMA), glucose(0-30) (area under the curve [AUC]) × insulin(0-30) (AUC) and liver insulin resistance (liver IR) indexes were computed. Liver IR index correlated more strongly than HOMA with GGT, ALK, hsCRP, ALT and AST and more strongly than glucose(0-30) (AUC) × insulin(0-30) (AUC) index with ALT, AST, GGT, ALK, hsCRP, and IGF-1. The ability of these indexes to identify NAFLD was evaluated by the area under the ROC curve; the ROC AUC for liver IR index was higher (0.733) than the ones for HOMA (0.685) and glucose(0-30) (AUC) × insulin(0-30) (AUC) (0.663) indexes. In a logistic regression model subjects in the highest quartile of the three indexes had a higher risk of having NAFLD than those in the lowest quartile (9.85-, 5.12- or 3.99-fold higher for liver IR index, HOMA, glucose(0-30) (AUC) × insulin(0-30) (AUC) index respectively). CONCLUSIONS: we documented significant cross-sectional associations of NAFLD and liver biomarkers with three validated indexes of hepatic insulin resistance, with liver IR index showing the stronger correlation. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/23419734/Association_of_hepatic_insulin_resistance_indexes_to_nonalcoholic_fatty_liver_disease_and_related_biomarkers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(13)00009-4 DB - PRIME DP - Unbound Medicine ER -