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Protein Z variants associated with protein Z plasma levels and with risk of idiopathic recurrent miscarriage.
Reprod Sci. 2013 Sep; 20(9):1062-8.RS

Abstract

Protein Z (PZ) deficiency due to anti-PZ autoantibodies and/or mutations in PZgene was linked with adverse pregnancy outcomes, including idiopathic recurrent miscarriage (IRM). We investigated the association of rs3024718, rs3024719, rs3024731, rs3024778, rs3024772, and rs3024735 (G79A) PZ variants and changes in PZ levels in 287 women with IRM, and 308 control women. Of the 6 single nucleotide polymorphisms (SNPs) analyzed, higher minor allele frequency of rs3024735 (G79A) and rs3024731 were seen in IRM cases than in control women. Significantly higher frequencies of rs3024735/G79A G/A and A/A (P< .001), rs3024719 G/A (P= .009), and rs3024731 A/A (P = .012), but not rs3024718 (P= .12), rs3024778 (P = .76), or rs3024772 (P= .27) genotype carriers were seen between IRM cases versus control women, respectively, and was linked with reduced PZ levels. Six-locus (rs3024718/rs3024719/rs3024778/rs3024731/rs3024735/rs3024772) PZhaplotypes analysis demonstrated increased frequency of GAGAAG and AGGTAG and reduced frequency of AGGTGC haplotypes in IRM cases, thereby conferring disease susceptibility and protective nature to these haplotypes, respectively. These results demonstrate that specific PZSNPs and haplotypes are significantly associated with IRM.

Authors+Show Affiliations

Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23420821

Citation

Al-Shaikh, Fatima S., et al. "Protein Z Variants Associated With Protein Z Plasma Levels and With Risk of Idiopathic Recurrent Miscarriage." Reproductive Sciences (Thousand Oaks, Calif.), vol. 20, no. 9, 2013, pp. 1062-8.
Al-Shaikh FS, Sater MS, Finan RR, et al. Protein Z variants associated with protein Z plasma levels and with risk of idiopathic recurrent miscarriage. Reprod Sci. 2013;20(9):1062-8.
Al-Shaikh, F. S., Sater, M. S., Finan, R. R., Racoubian, E., Abu-Hijleh, T. M., Mustafa, F. E., & Almawi, W. Y. (2013). Protein Z variants associated with protein Z plasma levels and with risk of idiopathic recurrent miscarriage. Reproductive Sciences (Thousand Oaks, Calif.), 20(9), 1062-8. https://doi.org/10.1177/1933719112473659
Al-Shaikh FS, et al. Protein Z Variants Associated With Protein Z Plasma Levels and With Risk of Idiopathic Recurrent Miscarriage. Reprod Sci. 2013;20(9):1062-8. PubMed PMID: 23420821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein Z variants associated with protein Z plasma levels and with risk of idiopathic recurrent miscarriage. AU - Al-Shaikh,Fatima S, AU - Sater,Mai S, AU - Finan,Ramzi R, AU - Racoubian,Eddie, AU - Abu-Hijleh,Tala M, AU - Mustafa,Fekria E, AU - Almawi,Wassim Y, Y1 - 2013/02/18/ PY - 2013/2/20/entrez PY - 2013/2/20/pubmed PY - 2014/1/21/medline KW - haplotypes KW - idiopathic recurrent miscarriage KW - protein Z SP - 1062 EP - 8 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 20 IS - 9 N2 - Protein Z (PZ) deficiency due to anti-PZ autoantibodies and/or mutations in PZgene was linked with adverse pregnancy outcomes, including idiopathic recurrent miscarriage (IRM). We investigated the association of rs3024718, rs3024719, rs3024731, rs3024778, rs3024772, and rs3024735 (G79A) PZ variants and changes in PZ levels in 287 women with IRM, and 308 control women. Of the 6 single nucleotide polymorphisms (SNPs) analyzed, higher minor allele frequency of rs3024735 (G79A) and rs3024731 were seen in IRM cases than in control women. Significantly higher frequencies of rs3024735/G79A G/A and A/A (P< .001), rs3024719 G/A (P= .009), and rs3024731 A/A (P = .012), but not rs3024718 (P= .12), rs3024778 (P = .76), or rs3024772 (P= .27) genotype carriers were seen between IRM cases versus control women, respectively, and was linked with reduced PZ levels. Six-locus (rs3024718/rs3024719/rs3024778/rs3024731/rs3024735/rs3024772) PZhaplotypes analysis demonstrated increased frequency of GAGAAG and AGGTAG and reduced frequency of AGGTGC haplotypes in IRM cases, thereby conferring disease susceptibility and protective nature to these haplotypes, respectively. These results demonstrate that specific PZSNPs and haplotypes are significantly associated with IRM. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/23420821/Protein_Z_variants_associated_with_protein_Z_plasma_levels_and_with_risk_of_idiopathic_recurrent_miscarriage_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719112473659?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -