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Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma.
J Urol. 1990 Jun; 143(6):1183-7.JU

Abstract

Seminal vesicle invasion and the percentage involvement by cancer of each seminal vesicle were related to cancer volume, quantitative histological grade and presence or absence of lymph node metastases in 243 radical prostatectomy specimens. There were 47 prostates with seminal vesicle invasion. Frequency and extent of seminal vesicle invasion were strongly correlated with cancer volume, with minimal invasion noted in only 6% of the cases less than 4 cc. The relationship of seminal vesicle invasion to lymph node metastasis was statistically significant but cancer volume and histological grade were much stronger predictors of lymph node metastasis. The route of invasion from the prostate in 46 cases involved direct tumor spread into the midbase region near the ejaculatory ducts. Seminal vesicle invasion often may not be identified if the tissue nearest the ejaculatory ducts at the prostate base is not sampled.

Authors+Show Affiliations

Villers AA
Division of Urology, Stanford University School of Medicine, California 94305-5118.
McNeal JE
No affiliation info available
Redwine EA
No affiliation info available
Freiha FS
No affiliation info available
Stamey TA
No affiliation info available

MeSH

AdenocarcinomaAdultAgedHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessProstateProstatic NeoplasmsSeminal Vesicles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2342179

Citation

Villers, A A., et al. "Pathogenesis and Biological Significance of Seminal Vesicle Invasion in Prostatic Adenocarcinoma." The Journal of Urology, vol. 143, no. 6, 1990, pp. 1183-7.
Villers AA, McNeal JE, Redwine EA, et al. Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. J Urol. 1990;143(6):1183-7.
Villers, A. A., McNeal, J. E., Redwine, E. A., Freiha, F. S., & Stamey, T. A. (1990). Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. The Journal of Urology, 143(6), 1183-7.
Villers AA, et al. Pathogenesis and Biological Significance of Seminal Vesicle Invasion in Prostatic Adenocarcinoma. J Urol. 1990;143(6):1183-7. PubMed PMID: 2342179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. AU - Villers,A A, AU - McNeal,J E, AU - Redwine,E A, AU - Freiha,F S, AU - Stamey,T A, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 1183 EP - 7 JF - The Journal of urology JO - J Urol VL - 143 IS - 6 N2 - Seminal vesicle invasion and the percentage involvement by cancer of each seminal vesicle were related to cancer volume, quantitative histological grade and presence or absence of lymph node metastases in 243 radical prostatectomy specimens. There were 47 prostates with seminal vesicle invasion. Frequency and extent of seminal vesicle invasion were strongly correlated with cancer volume, with minimal invasion noted in only 6% of the cases less than 4 cc. The relationship of seminal vesicle invasion to lymph node metastasis was statistically significant but cancer volume and histological grade were much stronger predictors of lymph node metastasis. The route of invasion from the prostate in 46 cases involved direct tumor spread into the midbase region near the ejaculatory ducts. Seminal vesicle invasion often may not be identified if the tissue nearest the ejaculatory ducts at the prostate base is not sampled. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/2342179/Pathogenesis_and_biological_significance_of_seminal_vesicle_invasion_in_prostatic_adenocarcinoma_ DB - PRIME DP - Unbound Medicine ER -