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Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov.
Fitoterapia. 2013 Apr; 86:70-7.F

Abstract

Five novel compounds - three sesquiterpene coumarin derivatives, ferulin A (1), B (2), and C (3), and two sesquiterpene chromone derivatives, ferulin D (4) and E (5), together with eleven known compounds (6-16) have been isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis. The biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compound 7 displayed the highest potency against HepG2, MCF-7, and C6 with IC50 values 39.9 μM, 37.7 μM, and 16.0 μM, respectively.

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Authors+Show Affiliations

Meng H
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Li G
No affiliation info available
Huang J
No affiliation info available
Zhang K
No affiliation info available
Wang H
No affiliation info available
Wang J
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicChromonesCoumarinsFerulaHep G2 CellsHumansInhibitory Concentration 50MCF-7 CellsMolecular StructureNeoplasmsPhytotherapyPlant ExtractsPlant RootsSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23422224

Citation

Meng, He, et al. "Sesquiterpene Coumarin and Sesquiterpene Chromone Derivatives From Ferula Ferulaeoides (Steud.) Korov." Fitoterapia, vol. 86, 2013, pp. 70-7.
Meng H, Li G, Huang J, et al. Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov. Fitoterapia. 2013;86:70-7.
Meng, H., Li, G., Huang, J., Zhang, K., Wang, H., & Wang, J. (2013). Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov. Fitoterapia, 86, 70-7. https://doi.org/10.1016/j.fitote.2013.02.002
Meng H, et al. Sesquiterpene Coumarin and Sesquiterpene Chromone Derivatives From Ferula Ferulaeoides (Steud.) Korov. Fitoterapia. 2013;86:70-7. PubMed PMID: 23422224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov. AU - Meng,He, AU - Li,Guoyu, AU - Huang,Jian, AU - Zhang,Ke, AU - Wang,Hangyu, AU - Wang,Jinhui, Y1 - 2013/02/17/ PY - 2012/08/09/received PY - 2013/02/02/revised PY - 2013/02/10/accepted PY - 2013/2/21/entrez PY - 2013/2/21/pubmed PY - 2013/12/16/medline SP - 70 EP - 7 JF - Fitoterapia JO - Fitoterapia VL - 86 N2 - Five novel compounds - three sesquiterpene coumarin derivatives, ferulin A (1), B (2), and C (3), and two sesquiterpene chromone derivatives, ferulin D (4) and E (5), together with eleven known compounds (6-16) have been isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis. The biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compound 7 displayed the highest potency against HepG2, MCF-7, and C6 with IC50 values 39.9 μM, 37.7 μM, and 16.0 μM, respectively. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/23422224/Sesquiterpene_coumarin_and_sesquiterpene_chromone_derivatives_from_Ferula_ferulaeoides__Steud___Korov_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(13)00036-1 DB - PRIME DP - Unbound Medicine ER -