TY - JOUR T1 - Hyperinsulinemia associated with acanthosis nigricans, finger pebbles, acrochordons, and the sign of Leser-Trélat. AU - Saraiya,Ami, AU - Al-Shoha,Ahmad, AU - Brodell,Robert T, PY - 2013/2/22/entrez PY - 2013/2/22/pubmed PY - 2014/2/20/medline SP - 522 EP - 5 JF - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JO - Endocr Pract VL - 19 IS - 3 N2 - OBJECTIVE: To review common skin manifestations associated with type 2 diabetes mellitus (DM), and to discuss a potential underlying mechanism for these manifestations. METHODS: A PubMed literature search was conducted for articles describing the skin manifestations associated with hyperinsulinemia and type 2 DM. A case presentation describes a morbidly obese patient with type 2 DM treated with metformin who developed acanthosis nigricans, finger pebbles, scores of skin tags (acrochordons), and the sign of Leser-Trélat (sudden onset shower of seborrheic keratoses) in the absence of internal malignancy. RESULTS: Acanthosis nigricans, acrochordons, and finger pebbles have been associated with type 2 DM and obesity. While the Leser-Trélat sign is classically associated with internal malignancy, it can also be idiopathic. To our knowledge, this the first report of the occurrence of the Leser-Trélat sign in a patient with DM absent internal malignancy. CONCLUSION: Several skin manifestations can be seen in this patient with DM because of underlying insulin resistance and subsequent stimulation of insulin-like growth factor receptors. Management strategies could include weight loss, diet, and insulin-sensitizing pharmacologic therapy. SN - 1934-2403 UR - https://www.unboundmedicine.com/medline/citation/23425641/Hyperinsulinemia_associated_with_acanthosis_nigricans_finger_pebbles_acrochordons_and_the_sign_of_Leser_Trélat_ DB - PRIME DP - Unbound Medicine ER -