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Walnut consumption is associated with lower risk of type 2 diabetes in women.
J Nutr. 2013 Apr; 143(4):512-8.JN

Abstract

Walnuts are rich in polyunsaturated fatty acids and have been shown to improve various cardiometabolic risk factors. We aimed to investigate the association between walnut intake and incident type 2 diabetes in 2 large cohort studies: the Nurses' Health Study (NHS) and NHS II. We prospectively followed 58,063 women aged 52-77 y in NHS (1998-2008) and 79,893 women aged 35-52 y in NHS II (1999-2009) without diabetes, cardiovascular disease, or cancer at baseline. Consumption of walnuts and other nuts was assessed every 4 y using validated food frequency questionnaires. Self-reported type 2 diabetes was confirmed by a validated supplemental questionnaire. We documented a total of 5930 incident type 2 diabetes cases during 10 y of follow-up. In the multivariable-adjusted Cox proportional hazards model without body mass index (BMI), walnut consumption was associated with a lower risk of type 2 diabetes, and the HRs (95% CIs) for participants consuming 1-3 servings/mo (1 serving = 28 g), 1 serving/wk, and ≥2 servings/wk of walnuts were 0.93 (0.88-0.99), 0.81 (0.70-0.94), and 0.67 (0.54-0.82) compared with women who never/rarely consumed walnuts (P-trend < 0.001). Further adjustment for updated BMI slightly attenuated the association and the HRs (95% CIs) were 0.96 (0.90-1.02), 0.87 (0.75-1.01), and 0.76 (0.62-0.94), respectively (P-trend = 0.002). The consumption of total nuts (P-trend < 0.001) and other tree nuts (P-trend = 0.03) was also inversely associated with risk of type 2 diabetes, and the associations were largely explained by BMI. Our results suggest that higher walnut consumption is associated with a significantly lower risk of type 2 diabetes in women.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23427333

Citation

Pan, An, et al. "Walnut Consumption Is Associated With Lower Risk of Type 2 Diabetes in Women." The Journal of Nutrition, vol. 143, no. 4, 2013, pp. 512-8.
Pan A, Sun Q, Manson JE, et al. Walnut consumption is associated with lower risk of type 2 diabetes in women. J Nutr. 2013;143(4):512-8.
Pan, A., Sun, Q., Manson, J. E., Willett, W. C., & Hu, F. B. (2013). Walnut consumption is associated with lower risk of type 2 diabetes in women. The Journal of Nutrition, 143(4), 512-8. https://doi.org/10.3945/jn.112.172171
Pan A, et al. Walnut Consumption Is Associated With Lower Risk of Type 2 Diabetes in Women. J Nutr. 2013;143(4):512-8. PubMed PMID: 23427333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Walnut consumption is associated with lower risk of type 2 diabetes in women. AU - Pan,An, AU - Sun,Qi, AU - Manson,JoAnn E, AU - Willett,Walter C, AU - Hu,Frank B, Y1 - 2013/02/20/ PY - 2013/2/22/entrez PY - 2013/2/22/pubmed PY - 2013/5/7/medline SP - 512 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 4 N2 - Walnuts are rich in polyunsaturated fatty acids and have been shown to improve various cardiometabolic risk factors. We aimed to investigate the association between walnut intake and incident type 2 diabetes in 2 large cohort studies: the Nurses' Health Study (NHS) and NHS II. We prospectively followed 58,063 women aged 52-77 y in NHS (1998-2008) and 79,893 women aged 35-52 y in NHS II (1999-2009) without diabetes, cardiovascular disease, or cancer at baseline. Consumption of walnuts and other nuts was assessed every 4 y using validated food frequency questionnaires. Self-reported type 2 diabetes was confirmed by a validated supplemental questionnaire. We documented a total of 5930 incident type 2 diabetes cases during 10 y of follow-up. In the multivariable-adjusted Cox proportional hazards model without body mass index (BMI), walnut consumption was associated with a lower risk of type 2 diabetes, and the HRs (95% CIs) for participants consuming 1-3 servings/mo (1 serving = 28 g), 1 serving/wk, and ≥2 servings/wk of walnuts were 0.93 (0.88-0.99), 0.81 (0.70-0.94), and 0.67 (0.54-0.82) compared with women who never/rarely consumed walnuts (P-trend < 0.001). Further adjustment for updated BMI slightly attenuated the association and the HRs (95% CIs) were 0.96 (0.90-1.02), 0.87 (0.75-1.01), and 0.76 (0.62-0.94), respectively (P-trend = 0.002). The consumption of total nuts (P-trend < 0.001) and other tree nuts (P-trend = 0.03) was also inversely associated with risk of type 2 diabetes, and the associations were largely explained by BMI. Our results suggest that higher walnut consumption is associated with a significantly lower risk of type 2 diabetes in women. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23427333/Walnut_consumption_is_associated_with_lower_risk_of_type_2_diabetes_in_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.172171 DB - PRIME DP - Unbound Medicine ER -