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Microbicides for the prevention of sexually transmitted HIV infection.
Expert Rev Anti Infect Ther. 2013 Jan; 11(1):13-23.ER

Abstract

The impetus for, and efforts in the past 20 years toward a women-initiated method for preventing sexual transmission of HIV has been previously well described. To date, four classes of topical agents categorized by mechanism of action as: surfactants, buffers, cell entry blockers and antiretroviral agents have undergone advanced clinical testing. Thus far, only coitally linked use of 1% tenofovir gel has demonstrated moderate effectiveness in preventing HIV and HSV-2 infection and has generated renewed hope for microbicide development. Studies of new antiviral agents, novel delivery mechanisms and combination/multipurpose products that address challenges of adherence and enhance the effectiveness of tenofovir gel are already underway to further enhance sexual and reproductive health needs of men and women and efforts to prevent HIV infection.

Authors+Show Affiliations

Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa. abdoolq2@ukzn.ac.zaNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23428099

Citation

Karim, Quarraisha Abdool, and Cheryl Baxter. "Microbicides for the Prevention of Sexually Transmitted HIV Infection." Expert Review of Anti-infective Therapy, vol. 11, no. 1, 2013, pp. 13-23.
Karim QA, Baxter C. Microbicides for the prevention of sexually transmitted HIV infection. Expert Rev Anti Infect Ther. 2013;11(1):13-23.
Karim, Q. A., & Baxter, C. (2013). Microbicides for the prevention of sexually transmitted HIV infection. Expert Review of Anti-infective Therapy, 11(1), 13-23. https://doi.org/10.1586/eri.12.153
Karim QA, Baxter C. Microbicides for the Prevention of Sexually Transmitted HIV Infection. Expert Rev Anti Infect Ther. 2013;11(1):13-23. PubMed PMID: 23428099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbicides for the prevention of sexually transmitted HIV infection. AU - Karim,Quarraisha Abdool, AU - Baxter,Cheryl, PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/11/1/medline SP - 13 EP - 23 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 11 IS - 1 N2 - The impetus for, and efforts in the past 20 years toward a women-initiated method for preventing sexual transmission of HIV has been previously well described. To date, four classes of topical agents categorized by mechanism of action as: surfactants, buffers, cell entry blockers and antiretroviral agents have undergone advanced clinical testing. Thus far, only coitally linked use of 1% tenofovir gel has demonstrated moderate effectiveness in preventing HIV and HSV-2 infection and has generated renewed hope for microbicide development. Studies of new antiviral agents, novel delivery mechanisms and combination/multipurpose products that address challenges of adherence and enhance the effectiveness of tenofovir gel are already underway to further enhance sexual and reproductive health needs of men and women and efforts to prevent HIV infection. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/23428099/Microbicides_for_the_prevention_of_sexually_transmitted_HIV_infection_ L2 - https://www.tandfonline.com/doi/full/10.1586/eri.12.153 DB - PRIME DP - Unbound Medicine ER -