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Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM).
J Ren Nutr. 2013 Mar; 23(2):77-90.JR

Abstract

Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW.

Links

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Authors+Show Affiliations

Carrero JJ
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden.
Stenvinkel P
No affiliation info available
Cuppari L
No affiliation info available
Ikizler TA
No affiliation info available
Kalantar-Zadeh K
No affiliation info available
Kaysen G
No affiliation info available
Mitch WE
No affiliation info available
Price SR
No affiliation info available
Wanner C
No affiliation info available
Wang AY
No affiliation info available
ter Wee P
No affiliation info available
Franch HA
No affiliation info available

MeSH

AdipokinesComorbidityConsensusEnergy MetabolismHumansInflammationLife StyleMotor ActivityNutritional StatusObesity, AbdominalPrevalenceProtein-Energy MalnutritionRenal DialysisRenal Insufficiency, ChronicWasting Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23428357

Clinical Trial Links

Effect of Oral Nutritional Supplementation on Oxidative Stress in Protein-energy Wasting Patients With Peritoneal Dialysis

Citation

Carrero, Juan Jesús, et al. "Etiology of the Protein-energy Wasting Syndrome in Chronic Kidney Disease: a Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 23, no. 2, 2013, pp. 77-90.
Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77-90.
Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar-Zadeh, K., Kaysen, G., Mitch, W. E., Price, S. R., Wanner, C., Wang, A. Y., ter Wee, P., & Franch, H. A. (2013). Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 23(2), 77-90. https://doi.org/10.1053/j.jrn.2013.01.001
Carrero JJ, et al. Etiology of the Protein-energy Wasting Syndrome in Chronic Kidney Disease: a Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77-90. PubMed PMID: 23428357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). AU - Carrero,Juan Jesús, AU - Stenvinkel,Peter, AU - Cuppari,Lilian, AU - Ikizler,T Alp, AU - Kalantar-Zadeh,Kamyar, AU - Kaysen,George, AU - Mitch,William E, AU - Price,S Russ, AU - Wanner,Christoph, AU - Wang,Angela Y M, AU - ter Wee,Pieter, AU - Franch,Harold A, PY - 2013/01/15/received PY - 2013/01/15/accepted PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/9/13/medline SP - 77 EP - 90 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 23 IS - 2 N2 - Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/23428357/Etiology_of_the_protein_energy_wasting_syndrome_in_chronic_kidney_disease:_a_consensus_statement_from_the_International_Society_of_Renal_Nutrition_and_Metabolism__ISRNM__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(13)00006-X DB - PRIME DP - Unbound Medicine ER -