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Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM).
J Ren Nutr 2013; 23(2):77-90JR

Abstract

Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW.

Authors+Show Affiliations

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23428357

Citation

Carrero, Juan Jesús, et al. "Etiology of the Protein-energy Wasting Syndrome in Chronic Kidney Disease: a Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 23, no. 2, 2013, pp. 77-90.
Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77-90.
Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar-Zadeh, K., Kaysen, G., ... Franch, H. A. (2013). Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 23(2), pp. 77-90. doi:10.1053/j.jrn.2013.01.001.
Carrero JJ, et al. Etiology of the Protein-energy Wasting Syndrome in Chronic Kidney Disease: a Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77-90. PubMed PMID: 23428357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). AU - Carrero,Juan Jesús, AU - Stenvinkel,Peter, AU - Cuppari,Lilian, AU - Ikizler,T Alp, AU - Kalantar-Zadeh,Kamyar, AU - Kaysen,George, AU - Mitch,William E, AU - Price,S Russ, AU - Wanner,Christoph, AU - Wang,Angela Y M, AU - ter Wee,Pieter, AU - Franch,Harold A, PY - 2013/01/15/received PY - 2013/01/15/accepted PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/9/13/medline SP - 77 EP - 90 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 23 IS - 2 N2 - Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/23428357/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(13)00006-X DB - PRIME DP - Unbound Medicine ER -