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A mechanism-based pharmacological evaluation of efficacy of Trigonella foenum graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats.
J Cardiovasc Pharmacol. 2013 Jun; 61(6):505-12.JC

Abstract

: Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet-induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin-cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%-45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties.

Authors+Show Affiliations

Departments of Biochemistry and Toxicology, Council of Scientific and Industrial Research, Central Drug Research Institute, New Delhi, India. .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23429594

Citation

Chaturvedi, Upma, et al. "A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella Foenum Graecum (fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats." Journal of Cardiovascular Pharmacology, vol. 61, no. 6, 2013, pp. 505-12.
Chaturvedi U, Shrivastava A, Bhadauria S, et al. A mechanism-based pharmacological evaluation of efficacy of Trigonella foenum graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. J Cardiovasc Pharmacol. 2013;61(6):505-12.
Chaturvedi, U., Shrivastava, A., Bhadauria, S., Saxena, J. K., & Bhatia, G. (2013). A mechanism-based pharmacological evaluation of efficacy of Trigonella foenum graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. Journal of Cardiovascular Pharmacology, 61(6), 505-12. https://doi.org/10.1097/FJC.0b013e31828b7822
Chaturvedi U, et al. A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella Foenum Graecum (fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats. J Cardiovasc Pharmacol. 2013;61(6):505-12. PubMed PMID: 23429594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A mechanism-based pharmacological evaluation of efficacy of Trigonella foenum graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. AU - Chaturvedi,Upma, AU - Shrivastava,Atul, AU - Bhadauria,Smriti, AU - Saxena,Jitendra K, AU - Bhatia,Gitika, PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/10/23/medline SP - 505 EP - 12 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 61 IS - 6 N2 - : Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet-induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin-cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%-45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties. SN - 1533-4023 UR - https://www.unboundmedicine.com/medline/citation/23429594/A_mechanism_based_pharmacological_evaluation_of_efficacy_of_Trigonella_foenum_graecum__fenugreek__seeds_in_regulation_of_dyslipidemia_and_oxidative_stress_in_hyperlipidemic_rats_ L2 - https://doi.org/10.1097/FJC.0b013e31828b7822 DB - PRIME DP - Unbound Medicine ER -