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Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study.
Ann Hematol. 2013 Jun; 92(6):731-7.AH

Abstract

This study aims to determine prevalence and incidence of anemia in the general population in Germany and evaluate a potential role of serum-free light chains (FLC) as biomarker in anemia. The population-based Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45-75 years. Hemoglobin <13 g/dl in men and <12 g/dl in women defined anemia. Laboratory data was used to classify cases into renal, iron deficiency (IDA), vitamin B12/folic acid deficiency, anemia of chronic disease (ACD), and unexplained anemia (UA). Follow-up data was available from annual questionnaires, death certificates, and 5-year follow-up visit (5-year FU). Anemia cases (152) were identified (prevalence 3.2 %, 95 % CI 2.7-3.7). In participants aged 65 or older, prevalence was 4.3 % (95 % CI 2.9-6.0) in both men and women. Main anemia subtypes were: IDA 19 %, ACD 25 %, and UA 44 %. Incidence increased with age and was 12.8/1,000 person-years and 10.9/1,000 person-years in men and women aged 65 or older, respectively. UA was characterized by elevated FLC. Participants with elevated FLC and high-sensitivity C-reactive protein (hsCRP) had an increased risk of anemia at 5-year FU. FLC-alone or in combination with hsCRP-may serve as biomarker indicating an increased risk of developing anemia.

Authors+Show Affiliations

Department of Hematology, University Hospital Essen, Essen, Germany. lewin.eisele@uni-due.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23430088

Citation

Eisele, Lewin, et al. "Prevalence and Incidence of Anemia in the German Heinz Nixdorf Recall Study." Annals of Hematology, vol. 92, no. 6, 2013, pp. 731-7.
Eisele L, Dürig J, Broecker-Preuss M, et al. Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study. Ann Hematol. 2013;92(6):731-7.
Eisele, L., Dürig, J., Broecker-Preuss, M., Dührsen, U., Bokhof, B., Erbel, R., Moebus, S., & Jöckel, K. H. (2013). Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study. Annals of Hematology, 92(6), 731-7. https://doi.org/10.1007/s00277-013-1697-1
Eisele L, et al. Prevalence and Incidence of Anemia in the German Heinz Nixdorf Recall Study. Ann Hematol. 2013;92(6):731-7. PubMed PMID: 23430088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study. AU - Eisele,Lewin, AU - Dürig,Jan, AU - Broecker-Preuss,Martina, AU - Dührsen,Ulrich, AU - Bokhof,Beate, AU - Erbel,Raimund, AU - Moebus,Susanne, AU - Jöckel,Karl-Heinz, AU - ,, Y1 - 2013/02/21/ PY - 2012/08/02/received PY - 2013/02/01/accepted PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/7/10/medline SP - 731 EP - 7 JF - Annals of hematology JO - Ann Hematol VL - 92 IS - 6 N2 - This study aims to determine prevalence and incidence of anemia in the general population in Germany and evaluate a potential role of serum-free light chains (FLC) as biomarker in anemia. The population-based Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45-75 years. Hemoglobin <13 g/dl in men and <12 g/dl in women defined anemia. Laboratory data was used to classify cases into renal, iron deficiency (IDA), vitamin B12/folic acid deficiency, anemia of chronic disease (ACD), and unexplained anemia (UA). Follow-up data was available from annual questionnaires, death certificates, and 5-year follow-up visit (5-year FU). Anemia cases (152) were identified (prevalence 3.2 %, 95 % CI 2.7-3.7). In participants aged 65 or older, prevalence was 4.3 % (95 % CI 2.9-6.0) in both men and women. Main anemia subtypes were: IDA 19 %, ACD 25 %, and UA 44 %. Incidence increased with age and was 12.8/1,000 person-years and 10.9/1,000 person-years in men and women aged 65 or older, respectively. UA was characterized by elevated FLC. Participants with elevated FLC and high-sensitivity C-reactive protein (hsCRP) had an increased risk of anemia at 5-year FU. FLC-alone or in combination with hsCRP-may serve as biomarker indicating an increased risk of developing anemia. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/23430088/Prevalence_and_incidence_of_anemia_in_the_German_Heinz_Nixdorf_Recall_Study_ L2 - https://dx.doi.org/10.1007/s00277-013-1697-1 DB - PRIME DP - Unbound Medicine ER -