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Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index.
PLoS One 2013; 8(2):e56898Plos

Abstract

Obesity and family history are the most important predictors for type 2 diabetes mellitus(T2DM) in the Chinese Han population. However, it is not known whether the genetic loci related to obesity are associated with the risk of developing T2DM in this population. The present case-control study evaluated the associations between five genetic loci for obesity and the pathogenesis of T2DM. The study included 1117 Chinese Han patients with T2DM, 1629 patients with pre-diabetes (impaired fasting glucose and impaired glucose tolerance, IFG/IGT) and 1113 control subjects residing in Beijing. Five genetic loci including rs2815752 near NEGR1, rs10938397 near GNPDA2, rs4074134 near BDNF, rs17782313 near MC4R and rs1084753 near KCTD15 were genotyped. The results showed an association between rs4074134-BDNF minor allele and T2DM irrespective of age, gender and body mass index (BMI) (OR = 0.87; 95%CI: 0.77-0.99, P = 0.04). This SNP was also associated with pre-diabetes (OR = 0.87; 95%CI: 0.77-0.97, P = 0.01) independently of age, gender and BMI. No associations were found between diabetes or pre-diabetes and any of the other SNP loci studied. Genotype-phenotype association analysis (adjusting for age and gender) showed rs4074134-BDNF to be associated with BMI, waist circumference, fasting and postprandial plasma glucose, fasting serum insulin, and HOMA-IR in subjects without T2DM. However, fasting and postprandial plasma glucose were the only significant factors after adjusting for BMI. These results suggest that the common variation of BDNF (rs4074134) is associated with T2DM independently of obesity in Chinese Han population. This variant also has an effect on plasma glucose concentration, BMI and insulin sensitivity.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23431394

Citation

Han, Xueyao, et al. "Rs4074134 Near BDNF Gene Is Associated With Type 2 Diabetes Mellitus in Chinese Han Population Independently of Body Mass Index." PloS One, vol. 8, no. 2, 2013, pp. e56898.
Han X, Luo Y, Zhang X, et al. Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index. PLoS ONE. 2013;8(2):e56898.
Han, X., Luo, Y., Zhang, X., Lv, C., Sun, X., Zhang, X., ... Ji, L. (2013). Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index. PloS One, 8(2), pp. e56898. doi:10.1371/journal.pone.0056898.
Han X, et al. Rs4074134 Near BDNF Gene Is Associated With Type 2 Diabetes Mellitus in Chinese Han Population Independently of Body Mass Index. PLoS ONE. 2013;8(2):e56898. PubMed PMID: 23431394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index. AU - Han,Xueyao, AU - Luo,Yingying, AU - Zhang,Xiuying, AU - Lv,Chao, AU - Sun,Xiuqin, AU - Zhang,Xiaomei, AU - Zhou,Xianghai, AU - Cai,Xiaoling, AU - Ren,Qian, AU - Ji,Linong, Y1 - 2013/02/19/ PY - 2012/11/17/received PY - 2013/01/15/accepted PY - 2013/2/23/entrez PY - 2013/2/23/pubmed PY - 2013/8/16/medline SP - e56898 EP - e56898 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - Obesity and family history are the most important predictors for type 2 diabetes mellitus(T2DM) in the Chinese Han population. However, it is not known whether the genetic loci related to obesity are associated with the risk of developing T2DM in this population. The present case-control study evaluated the associations between five genetic loci for obesity and the pathogenesis of T2DM. The study included 1117 Chinese Han patients with T2DM, 1629 patients with pre-diabetes (impaired fasting glucose and impaired glucose tolerance, IFG/IGT) and 1113 control subjects residing in Beijing. Five genetic loci including rs2815752 near NEGR1, rs10938397 near GNPDA2, rs4074134 near BDNF, rs17782313 near MC4R and rs1084753 near KCTD15 were genotyped. The results showed an association between rs4074134-BDNF minor allele and T2DM irrespective of age, gender and body mass index (BMI) (OR = 0.87; 95%CI: 0.77-0.99, P = 0.04). This SNP was also associated with pre-diabetes (OR = 0.87; 95%CI: 0.77-0.97, P = 0.01) independently of age, gender and BMI. No associations were found between diabetes or pre-diabetes and any of the other SNP loci studied. Genotype-phenotype association analysis (adjusting for age and gender) showed rs4074134-BDNF to be associated with BMI, waist circumference, fasting and postprandial plasma glucose, fasting serum insulin, and HOMA-IR in subjects without T2DM. However, fasting and postprandial plasma glucose were the only significant factors after adjusting for BMI. These results suggest that the common variation of BDNF (rs4074134) is associated with T2DM independently of obesity in Chinese Han population. This variant also has an effect on plasma glucose concentration, BMI and insulin sensitivity. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23431394/Rs4074134_near_BDNF_gene_is_associated_with_type_2_diabetes_mellitus_in_Chinese_Han_population_independently_of_body_mass_index_ L2 - http://dx.plos.org/10.1371/journal.pone.0056898 DB - PRIME DP - Unbound Medicine ER -