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Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia.
J Agric Food Chem. 2013 Mar 27; 61(12):2979-86.JA

Abstract

This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A-D (1-4), along with 11 known ones, charantoside A (5), momordicosides I (6), F1 (7), F2 (8), K (9), L (10), and U (11), goyaglycosides-b (12) and -d (13), 7β,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-β-d-allopyranoside (14), and 25-hydroxy-5β,19-epoxycucurbita-6,23-dien-19-on-3β-ol 3-O-β-d-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified. Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hsiao PC
Divison of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
Liaw CC
No affiliation info available
Hwang SY
No affiliation info available
Cheng HL
No affiliation info available
Zhang LJ
No affiliation info available
Shen CC
No affiliation info available
Hsu FL
No affiliation info available
Kuo YH
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicCell LineCell Line, TumorCell ProliferationChromatography, High Pressure LiquidFruitGlycosidesHumansHypoglycemic AgentsMiceMolecular StructureMomordica charantiaPlant ExtractsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23432055

Citation

Hsiao, Ping-Chun, et al. "Antiproliferative and Hypoglycemic Cucurbitane-type Glycosides From the Fruits of Momordica Charantia." Journal of Agricultural and Food Chemistry, vol. 61, no. 12, 2013, pp. 2979-86.
Hsiao PC, Liaw CC, Hwang SY, et al. Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. J Agric Food Chem. 2013;61(12):2979-86.
Hsiao, P. C., Liaw, C. C., Hwang, S. Y., Cheng, H. L., Zhang, L. J., Shen, C. C., Hsu, F. L., & Kuo, Y. H. (2013). Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. Journal of Agricultural and Food Chemistry, 61(12), 2979-86. https://doi.org/10.1021/jf3041116
Hsiao PC, et al. Antiproliferative and Hypoglycemic Cucurbitane-type Glycosides From the Fruits of Momordica Charantia. J Agric Food Chem. 2013 Mar 27;61(12):2979-86. PubMed PMID: 23432055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. AU - Hsiao,Ping-Chun, AU - Liaw,Chia-Ching, AU - Hwang,Syh-Yuan, AU - Cheng,Hui-Ling, AU - Zhang,Li-Jie, AU - Shen,Chien-Chang, AU - Hsu,Feng-Lin, AU - Kuo,Yao-Haur, Y1 - 2013/03/12/ PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/12/16/medline SP - 2979 EP - 86 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 61 IS - 12 N2 - This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A-D (1-4), along with 11 known ones, charantoside A (5), momordicosides I (6), F1 (7), F2 (8), K (9), L (10), and U (11), goyaglycosides-b (12) and -d (13), 7β,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-β-d-allopyranoside (14), and 25-hydroxy-5β,19-epoxycucurbita-6,23-dien-19-on-3β-ol 3-O-β-d-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified. Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/23432055/Antiproliferative_and_hypoglycemic_cucurbitane_type_glycosides_from_the_fruits_of_Momordica_charantia_ L2 - https://doi.org/10.1021/jf3041116 DB - PRIME DP - Unbound Medicine ER -