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Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome.
Oral Oncol. 2013 Jun; 49(6):576-81.OO

Abstract

OBJECTIVES

Novel therapies are required for patients with recurrent or metastatic oral tongue squamous cell carcinoma (OTSCC). Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies. This study examined the frequency and clinical associations of FGFR1 amplification in OTSCC.

MATERIALS AND METHODS

The frequency of FGFR1 amplification determined by fluorescence in situ hybridization was evaluated in a cohort of 123 OTSCC patients. Associations of FGFR1 amplification with clinical characteristics and outcome were determined.

RESULTS

FGFR1 gene amplification was present in 9.3% (10/107) of cases and was significantly associated with smoking status (P = 0.03). FGFR1 amplification was seen more commonly in males (9/10 amplified cases male, P = 0.16) and there were no associations with age, stage, T stage, nodal status, alcohol history or performance status (all P>0.05). Outcome was not significantly different between FGFR1 amplified and non-amplified patients.

CONCLUSIONS

Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC.

Authors+Show Affiliations

Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23434054

Citation

Young, Richard J., et al. "Frequency of Fibroblast Growth Factor Receptor 1 Gene Amplification in Oral Tongue Squamous Cell Carcinomas and Associations With Clinical Features and Patient Outcome." Oral Oncology, vol. 49, no. 6, 2013, pp. 576-81.
Young RJ, Lim AM, Angel C, et al. Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. Oral Oncol. 2013;49(6):576-81.
Young, R. J., Lim, A. M., Angel, C., Collins, M., Deb, S., Corry, J., Wiesenfeld, D., Kleid, S., Sigston, E., Lyons, B., Russell, P. A., Wright, G., McArthur, G. A., Fox, S. B., Rischin, D., & Solomon, B. (2013). Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. Oral Oncology, 49(6), 576-81. https://doi.org/10.1016/j.oraloncology.2013.01.006
Young RJ, et al. Frequency of Fibroblast Growth Factor Receptor 1 Gene Amplification in Oral Tongue Squamous Cell Carcinomas and Associations With Clinical Features and Patient Outcome. Oral Oncol. 2013;49(6):576-81. PubMed PMID: 23434054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. AU - Young,Richard J, AU - Lim,Annette M, AU - Angel,Christopher, AU - Collins,Marnie, AU - Deb,Siddhartha, AU - Corry,June, AU - Wiesenfeld,David, AU - Kleid,Stephen, AU - Sigston,Elizabeth, AU - Lyons,Bernard, AU - Russell,Prudence A, AU - Wright,Gavin, AU - McArthur,Grant A, AU - Fox,Stephen B, AU - Rischin,Danny, AU - Solomon,Benjamin, Y1 - 2013/02/19/ PY - 2012/09/24/received PY - 2013/01/13/revised PY - 2013/01/19/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/12/16/medline SP - 576 EP - 81 JF - Oral oncology JO - Oral Oncol VL - 49 IS - 6 N2 - OBJECTIVES: Novel therapies are required for patients with recurrent or metastatic oral tongue squamous cell carcinoma (OTSCC). Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies. This study examined the frequency and clinical associations of FGFR1 amplification in OTSCC. MATERIALS AND METHODS: The frequency of FGFR1 amplification determined by fluorescence in situ hybridization was evaluated in a cohort of 123 OTSCC patients. Associations of FGFR1 amplification with clinical characteristics and outcome were determined. RESULTS: FGFR1 gene amplification was present in 9.3% (10/107) of cases and was significantly associated with smoking status (P = 0.03). FGFR1 amplification was seen more commonly in males (9/10 amplified cases male, P = 0.16) and there were no associations with age, stage, T stage, nodal status, alcohol history or performance status (all P>0.05). Outcome was not significantly different between FGFR1 amplified and non-amplified patients. CONCLUSIONS: Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC. SN - 1879-0593 UR - https://www.unboundmedicine.com/medline/citation/23434054/Frequency_of_fibroblast_growth_factor_receptor_1_gene_amplification_in_oral_tongue_squamous_cell_carcinomas_and_associations_with_clinical_features_and_patient_outcome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(13)00028-6 DB - PRIME DP - Unbound Medicine ER -