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The role of omega-3 derived resolvins in arthritis.
Curr Opin Pharmacol 2013; 13(3):476-81CO

Abstract

Omega-3 polyunsaturated fatty acids (PUFAs) are known to alleviate joint stiffness and pain in rheumatoid arthritis patients. However, the mechanisms by which omega-3s exert their beneficial effects has not been fully explored. Herein we discuss a novel class of bioactive lipid mediators, which are enzymatically biosynthesized in vivo from omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), termed resolvins. These lipid mediators exert anti-inflammatory and pro-resolving properties and are log-orders more potent than their precursors. We also highlight that formation of pro-resolving mediators can be enhanced by widely used anti-inflammatory and cardioprotective drugs (aspirin and statins) via the modification of cyclooxygenase-2 enzymatic activity. These bioactive pro-resolving lipid mediators provide further rationale for the beneficial effects of dietary supplementation with fish oils, and offer new avenues for developing therapeutics for inflammatory conditions such as rheumatoid arthritis.

Authors+Show Affiliations

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. l.v.norling@qmul.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23434193

Citation

Norling, Lucy V., and Mauro Perretti. "The Role of Omega-3 Derived Resolvins in Arthritis." Current Opinion in Pharmacology, vol. 13, no. 3, 2013, pp. 476-81.
Norling LV, Perretti M. The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol. 2013;13(3):476-81.
Norling, L. V., & Perretti, M. (2013). The role of omega-3 derived resolvins in arthritis. Current Opinion in Pharmacology, 13(3), pp. 476-81. doi:10.1016/j.coph.2013.02.003.
Norling LV, Perretti M. The Role of Omega-3 Derived Resolvins in Arthritis. Curr Opin Pharmacol. 2013;13(3):476-81. PubMed PMID: 23434193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of omega-3 derived resolvins in arthritis. AU - Norling,Lucy V, AU - Perretti,Mauro, Y1 - 2013/02/21/ PY - 2012/12/18/received PY - 2013/02/01/revised PY - 2013/02/04/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2014/1/17/medline SP - 476 EP - 81 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 13 IS - 3 N2 - Omega-3 polyunsaturated fatty acids (PUFAs) are known to alleviate joint stiffness and pain in rheumatoid arthritis patients. However, the mechanisms by which omega-3s exert their beneficial effects has not been fully explored. Herein we discuss a novel class of bioactive lipid mediators, which are enzymatically biosynthesized in vivo from omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), termed resolvins. These lipid mediators exert anti-inflammatory and pro-resolving properties and are log-orders more potent than their precursors. We also highlight that formation of pro-resolving mediators can be enhanced by widely used anti-inflammatory and cardioprotective drugs (aspirin and statins) via the modification of cyclooxygenase-2 enzymatic activity. These bioactive pro-resolving lipid mediators provide further rationale for the beneficial effects of dietary supplementation with fish oils, and offer new avenues for developing therapeutics for inflammatory conditions such as rheumatoid arthritis. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/23434193/The_role_of_omega_3_derived_resolvins_in_arthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(13)00018-0 DB - PRIME DP - Unbound Medicine ER -