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Circulating high-sensitivity C-reactive protein and soluble CD40 ligand are inter-related in a cohort of women with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2013 Jun; 168(2):178-82.EJ

Abstract

OBJECTIVE

Insulin resistance (IR), the fundamental metabolic alteration in women with polycystic ovary syndrome (PCOS), has recently been reported to represent, in part, a chronic low-grade inflammatory state. This study aimed to assess the inter-relationship between the plasma levels of high-sensitivity C-reactive protein (hs-CRP) and soluble CD40 ligand (sCD40L) - both inflammatory factors - and the pathogenesis of IR among women with PCOS.

STUDY DESIGN

This study compared 44 women with PCOS with a group of control women without PCOS (n = 39). Participants were matched for age, blood pressure and degree of obesity. Enzyme-linked immunosorbent assay was used to measure the two inflammatory factors. Fasting glucose and insulin were assayed and used to calculate the IR indices.

RESULTS

Significant elevations in the plasma levels of both inflammatory factors were observed in women with PCOS compared with the control women: 3.17 (2.23-3.89) vs 2.05 (0.93-2.82) mg/l for hs-CRP and 2.46 (1.08-4.16) vs 0.82 (0.43-1.26) ng/ml for sCD40L, respectively. Interestingly, among women with PCOS, the two inflammatory factors were significantly positively correlated with each other (r = 0.465, p = 0.002), as well as with the IR indices. This association remained significant even after adjustment for body mass index as a measure of obesity.

CONCLUSION

Independent of obesity, women with PCOS suffer low-grade inflammation that is correlated with IR. The observed inter-relationships suggest that CRP in collaboration with the CD40-CD40L system may have a role in the pathogenesis of PCOS.

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Authors+Show Affiliations

El-Mesallamy HO
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, Egypt.
Abd El-Razek RS
No affiliation info available
El-Refaie TA
No affiliation info available

MeSH

AdultBiomarkersBody Mass IndexC-Reactive ProteinCD40 LigandCase-Control StudiesCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansInsulin ResistanceObesityOverweightPolycystic Ovary SyndromeSolubilityUp-RegulationYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23434327

Citation

El-Mesallamy, H O., et al. "Circulating High-sensitivity C-reactive Protein and Soluble CD40 Ligand Are Inter-related in a Cohort of Women With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 168, no. 2, 2013, pp. 178-82.
El-Mesallamy HO, Abd El-Razek RS, El-Refaie TA. Circulating high-sensitivity C-reactive protein and soluble CD40 ligand are inter-related in a cohort of women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):178-82.
El-Mesallamy, H. O., Abd El-Razek, R. S., & El-Refaie, T. A. (2013). Circulating high-sensitivity C-reactive protein and soluble CD40 ligand are inter-related in a cohort of women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 168(2), 178-82. https://doi.org/10.1016/j.ejogrb.2013.01.015
El-Mesallamy HO, Abd El-Razek RS, El-Refaie TA. Circulating High-sensitivity C-reactive Protein and Soluble CD40 Ligand Are Inter-related in a Cohort of Women With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):178-82. PubMed PMID: 23434327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating high-sensitivity C-reactive protein and soluble CD40 ligand are inter-related in a cohort of women with polycystic ovary syndrome. AU - El-Mesallamy,H O, AU - Abd El-Razek,R S, AU - El-Refaie,T A, Y1 - 2013/02/21/ PY - 2012/06/13/received PY - 2012/09/08/revised PY - 2013/01/24/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/10/23/medline SP - 178 EP - 82 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 168 IS - 2 N2 - OBJECTIVE: Insulin resistance (IR), the fundamental metabolic alteration in women with polycystic ovary syndrome (PCOS), has recently been reported to represent, in part, a chronic low-grade inflammatory state. This study aimed to assess the inter-relationship between the plasma levels of high-sensitivity C-reactive protein (hs-CRP) and soluble CD40 ligand (sCD40L) - both inflammatory factors - and the pathogenesis of IR among women with PCOS. STUDY DESIGN: This study compared 44 women with PCOS with a group of control women without PCOS (n = 39). Participants were matched for age, blood pressure and degree of obesity. Enzyme-linked immunosorbent assay was used to measure the two inflammatory factors. Fasting glucose and insulin were assayed and used to calculate the IR indices. RESULTS: Significant elevations in the plasma levels of both inflammatory factors were observed in women with PCOS compared with the control women: 3.17 (2.23-3.89) vs 2.05 (0.93-2.82) mg/l for hs-CRP and 2.46 (1.08-4.16) vs 0.82 (0.43-1.26) ng/ml for sCD40L, respectively. Interestingly, among women with PCOS, the two inflammatory factors were significantly positively correlated with each other (r = 0.465, p = 0.002), as well as with the IR indices. This association remained significant even after adjustment for body mass index as a measure of obesity. CONCLUSION: Independent of obesity, women with PCOS suffer low-grade inflammation that is correlated with IR. The observed inter-relationships suggest that CRP in collaboration with the CD40-CD40L system may have a role in the pathogenesis of PCOS. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/23434327/Circulating_high_sensitivity_C_reactive_protein_and_soluble_CD40_ligand_are_inter_related_in_a_cohort_of_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(13)00058-4 DB - PRIME DP - Unbound Medicine ER -