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Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials.
PLoS One 2013; 8(2):e56803Plos

Abstract

BACKGROUND

Antioxidant vitamin (vitamin E, beta-carotene, and vitamin C) are widely used for preventing major cardiovascular outcomes. However, the effect of antioxidant vitamin on cardiovascular events remains unclear.

METHODOLOGY AND PRINCIPAL FINDINGS

We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, and the proceedings of major conferences for relevant literature. Eligible studies were randomized controlled trials that reported on the effects of antioxidant vitamin on cardiovascular outcomes as compared to placebo. Outcomes analyzed were major cardiovascular events, myocardial infarction, stroke, cardiac death, total death, and any possible adverse events. We used the I(2) statistic to measure heterogeneity between trials and calculated risk estimates for cardiovascular outcomes with random-effect meta-analysis. Independent extraction was performed by two reviewers and consensus was reached. Of 293 identified studies, we included 15 trials reporting data on 188209 participants. These studies reported 12749 major cardiovascular events, 6699 myocardial infarction, 3749 strokes, 14122 total death, and 5980 cardiac deaths. Overall, antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96-1.03), myocardial infarction (RR, 0.98; 95%CI, 0.92-1.04), stroke (RR, 0.99; 95%CI, 0.93-1.05), total death (RR, 1.03; 95%CI, 0.98-1.07), cardiac death (RR, 1.02; 95%CI, 0.97-1.07), revascularization (RR, 1.00; 95%CI, 0.95-1.05), total CHD (RR, 0.96; 95%CI, 0.87-1.05), angina (RR, 0.98; 95%CI, 0.90-1.07), and congestive heart failure (RR, 1.07; 95%CI, 0.96 to 1.19).

CONCLUSION/SIGNIFICANCE

Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.

Authors+Show Affiliations

Department of Cardiovascular Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23437244

Citation

Ye, Yizhou, et al. "Effect of Antioxidant Vitamin Supplementation On Cardiovascular Outcomes: a Meta-analysis of Randomized Controlled Trials." PloS One, vol. 8, no. 2, 2013, pp. e56803.
Ye Y, Li J, Yuan Z. Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS ONE. 2013;8(2):e56803.
Ye, Y., Li, J., & Yuan, Z. (2013). Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PloS One, 8(2), pp. e56803. doi:10.1371/journal.pone.0056803.
Ye Y, Li J, Yuan Z. Effect of Antioxidant Vitamin Supplementation On Cardiovascular Outcomes: a Meta-analysis of Randomized Controlled Trials. PLoS ONE. 2013;8(2):e56803. PubMed PMID: 23437244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. AU - Ye,Yizhou, AU - Li,Jing, AU - Yuan,Zhongxiang, Y1 - 2013/02/20/ PY - 2012/10/07/received PY - 2013/01/16/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/8/24/medline SP - e56803 EP - e56803 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - BACKGROUND: Antioxidant vitamin (vitamin E, beta-carotene, and vitamin C) are widely used for preventing major cardiovascular outcomes. However, the effect of antioxidant vitamin on cardiovascular events remains unclear. METHODOLOGY AND PRINCIPAL FINDINGS: We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, and the proceedings of major conferences for relevant literature. Eligible studies were randomized controlled trials that reported on the effects of antioxidant vitamin on cardiovascular outcomes as compared to placebo. Outcomes analyzed were major cardiovascular events, myocardial infarction, stroke, cardiac death, total death, and any possible adverse events. We used the I(2) statistic to measure heterogeneity between trials and calculated risk estimates for cardiovascular outcomes with random-effect meta-analysis. Independent extraction was performed by two reviewers and consensus was reached. Of 293 identified studies, we included 15 trials reporting data on 188209 participants. These studies reported 12749 major cardiovascular events, 6699 myocardial infarction, 3749 strokes, 14122 total death, and 5980 cardiac deaths. Overall, antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96-1.03), myocardial infarction (RR, 0.98; 95%CI, 0.92-1.04), stroke (RR, 0.99; 95%CI, 0.93-1.05), total death (RR, 1.03; 95%CI, 0.98-1.07), cardiac death (RR, 1.02; 95%CI, 0.97-1.07), revascularization (RR, 1.00; 95%CI, 0.95-1.05), total CHD (RR, 0.96; 95%CI, 0.87-1.05), angina (RR, 0.98; 95%CI, 0.90-1.07), and congestive heart failure (RR, 1.07; 95%CI, 0.96 to 1.19). CONCLUSION/SIGNIFICANCE: Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23437244/Effect_of_antioxidant_vitamin_supplementation_on_cardiovascular_outcomes:_a_meta_analysis_of_randomized_controlled_trials_ L2 - http://dx.plos.org/10.1371/journal.pone.0056803 DB - PRIME DP - Unbound Medicine ER -