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Higher fish intake is associated with a lower risk of hip fractures in Chinese men and women: a matched case-control study.

Abstract

OBJECTIVES

Fish is rich in nutrients that are favorable to bone health, but limited data are available regarding the relationship between fish intake and hip fractures. Our study examined the association between habitual fish intake and risk of hip fractures.

METHODS

A case-control study was performed between June 2009 and June 2012 in Guangdong Province, China. Five hundred and eighty-one hip fracture incident cases, aged 55 to 80 years (mean: 71 years), were enrolled from four hospitals. 1∶1 matched controls by gender and age (±3 years) were also recruited from communities and hospitals. Face-to-face interviews were used to obtain habitual dietary intake and information on various covariates.

RESULTS

Univariate conditional logistic regression analyses showed significantly dose-dependent inverse correlations between the risk of hip fractures and the intake of fresh-water fish, sea fish, mollusca, shellfish, and total fish in all of the subjects (p-trend: <0.001-0.016). After adjusting for covariates, the associations were slightly attenuated but remained significant for all (p-trend: <0.001-0.017) except for fresh-water fish (p = 0.553). The ORs (95%CI) of hip fractures for the highest (vs. lowest) quartile were 0.80 (0.48-1.31) for fresh-water fish, 0.31 (0.18-0.52) for sea fish, 0.55 (0.34-0.88) for mollusca and shellfish, and 0.47 (0.28-0.79) for total fish, respectively. Stratified and interaction analyses showed that the association was more significant in males than in females (p-interaction = 0.052).

CONCLUSION

Higher intake of seafood is independently associated with lower risk of hip fractures in elderly Chinese. Increasing consumption of sea fish may benefit the prevention of hip fractures in this population.

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  • Authors+Show Affiliations

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.

    , , , , , ,

    Source

    PloS one 8:2 2013 pg e56849

    MeSH

    Aged
    Case-Control Studies
    Diet
    Eating
    Female
    Fish Products
    Hip Fractures
    Humans
    Male
    Middle Aged
    Odds Ratio
    Risk

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23437256

    Citation

    Fan, Fan, et al. "Higher Fish Intake Is Associated With a Lower Risk of Hip Fractures in Chinese Men and Women: a Matched Case-control Study." PloS One, vol. 8, no. 2, 2013, pp. e56849.
    Fan F, Xue WQ, Wu BH, et al. Higher fish intake is associated with a lower risk of hip fractures in Chinese men and women: a matched case-control study. PLoS ONE. 2013;8(2):e56849.
    Fan, F., Xue, W. Q., Wu, B. H., He, M. G., Xie, H. L., Ouyang, W. F., ... Chen, Y. M. (2013). Higher fish intake is associated with a lower risk of hip fractures in Chinese men and women: a matched case-control study. PloS One, 8(2), pp. e56849. doi:10.1371/journal.pone.0056849.
    Fan F, et al. Higher Fish Intake Is Associated With a Lower Risk of Hip Fractures in Chinese Men and Women: a Matched Case-control Study. PLoS ONE. 2013;8(2):e56849. PubMed PMID: 23437256.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Higher fish intake is associated with a lower risk of hip fractures in Chinese men and women: a matched case-control study. AU - Fan,Fan, AU - Xue,Wen-Qiong, AU - Wu,Bao-Hua, AU - He,Ming-Guang, AU - Xie,Hai-Li, AU - Ouyang,Wei-Fu, AU - Tu,Su-Lan, AU - Chen,Yu-Ming, Y1 - 2013/02/20/ PY - 2012/10/17/received PY - 2013/01/15/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/8/24/medline SP - e56849 EP - e56849 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - OBJECTIVES: Fish is rich in nutrients that are favorable to bone health, but limited data are available regarding the relationship between fish intake and hip fractures. Our study examined the association between habitual fish intake and risk of hip fractures. METHODS: A case-control study was performed between June 2009 and June 2012 in Guangdong Province, China. Five hundred and eighty-one hip fracture incident cases, aged 55 to 80 years (mean: 71 years), were enrolled from four hospitals. 1∶1 matched controls by gender and age (±3 years) were also recruited from communities and hospitals. Face-to-face interviews were used to obtain habitual dietary intake and information on various covariates. RESULTS: Univariate conditional logistic regression analyses showed significantly dose-dependent inverse correlations between the risk of hip fractures and the intake of fresh-water fish, sea fish, mollusca, shellfish, and total fish in all of the subjects (p-trend: <0.001-0.016). After adjusting for covariates, the associations were slightly attenuated but remained significant for all (p-trend: <0.001-0.017) except for fresh-water fish (p = 0.553). The ORs (95%CI) of hip fractures for the highest (vs. lowest) quartile were 0.80 (0.48-1.31) for fresh-water fish, 0.31 (0.18-0.52) for sea fish, 0.55 (0.34-0.88) for mollusca and shellfish, and 0.47 (0.28-0.79) for total fish, respectively. Stratified and interaction analyses showed that the association was more significant in males than in females (p-interaction = 0.052). CONCLUSION: Higher intake of seafood is independently associated with lower risk of hip fractures in elderly Chinese. Increasing consumption of sea fish may benefit the prevention of hip fractures in this population. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23437256/Higher_fish_intake_is_associated_with_a_lower_risk_of_hip_fractures_in_Chinese_men_and_women:_a_matched_case_control_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0056849 DB - PRIME DP - Unbound Medicine ER -