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Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring.
PLoS One. 2013; 8(2):e57608.Plos

Abstract

Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the developing hypothalamic-pituitary-adrenal (HPA) system. Therefore, the present study investigated long-term effects of maternal adversity and/or SSRI medication use on nociception of adult Sprague-Dawley rat offspring, taking into account involvement of the HPA system. Dams were subject to stress during gestation and were treated with fluoxetine (2×/5 mg/kg/day) prior to parturition and throughout lactation. Four groups of adult male offspring were used: 1. Control+Vehicle, 2. Control+Fluoxetine, 3. Prenatal Stress+Vehicle, 4. Prenatal Stress+Fluoxetine. Results show that post-operative pain, measured as hypersensitivity to mechanical stimuli after hind paw incision, was decreased in adult offspring subject to prenatal stress alone and increased in offspring developmentally exposed to fluoxetine alone. Moreover, post-operative pain was normalized in prenatally stressed offspring exposed to fluoxetine. This was paralleled by a decrease in corticosteroid binding globulin (CBG) levels in prenatally stressed offspring and a normalization of serum CBG levels in prenatally stressed offspring developmentally exposed to fluoxetine. Thus, developmental fluoxetine exposure normalizes the long-term effects of maternal adversity on post-operative pain in offspring and these effects may be due, in part, to the involvement of the HPA system.

Authors+Show Affiliations

Department of Anesthesiology/Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23437400

Citation

Knaepen, Liesbeth, et al. "Developmental Fluoxetine Exposure Normalizes the Long-term Effects of Maternal Stress On Post-operative Pain in Sprague-Dawley Rat Offspring." PloS One, vol. 8, no. 2, 2013, pp. e57608.
Knaepen L, Rayen I, Charlier TD, et al. Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring. PLoS One. 2013;8(2):e57608.
Knaepen, L., Rayen, I., Charlier, T. D., Fillet, M., Houbart, V., van Kleef, M., Steinbusch, H. W., Patijn, J., Tibboel, D., Joosten, E. A., & Pawluski, J. L. (2013). Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring. PloS One, 8(2), e57608. https://doi.org/10.1371/journal.pone.0057608
Knaepen L, et al. Developmental Fluoxetine Exposure Normalizes the Long-term Effects of Maternal Stress On Post-operative Pain in Sprague-Dawley Rat Offspring. PLoS One. 2013;8(2):e57608. PubMed PMID: 23437400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring. AU - Knaepen,Liesbeth, AU - Rayen,Ine, AU - Charlier,Thierry D, AU - Fillet,Marianne, AU - Houbart,Virginie, AU - van Kleef,Maarten, AU - Steinbusch,Harry W, AU - Patijn,Jacob, AU - Tibboel,Dick, AU - Joosten,Elbert A, AU - Pawluski,Jodi L, Y1 - 2013/02/21/ PY - 2012/12/02/received PY - 2013/01/22/accepted PY - 2013/2/26/entrez PY - 2013/2/26/pubmed PY - 2013/8/7/medline SP - e57608 EP - e57608 JF - PloS one JO - PLoS One VL - 8 IS - 2 N2 - Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the developing hypothalamic-pituitary-adrenal (HPA) system. Therefore, the present study investigated long-term effects of maternal adversity and/or SSRI medication use on nociception of adult Sprague-Dawley rat offspring, taking into account involvement of the HPA system. Dams were subject to stress during gestation and were treated with fluoxetine (2×/5 mg/kg/day) prior to parturition and throughout lactation. Four groups of adult male offspring were used: 1. Control+Vehicle, 2. Control+Fluoxetine, 3. Prenatal Stress+Vehicle, 4. Prenatal Stress+Fluoxetine. Results show that post-operative pain, measured as hypersensitivity to mechanical stimuli after hind paw incision, was decreased in adult offspring subject to prenatal stress alone and increased in offspring developmentally exposed to fluoxetine alone. Moreover, post-operative pain was normalized in prenatally stressed offspring exposed to fluoxetine. This was paralleled by a decrease in corticosteroid binding globulin (CBG) levels in prenatally stressed offspring and a normalization of serum CBG levels in prenatally stressed offspring developmentally exposed to fluoxetine. Thus, developmental fluoxetine exposure normalizes the long-term effects of maternal adversity on post-operative pain in offspring and these effects may be due, in part, to the involvement of the HPA system. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23437400/Developmental_fluoxetine_exposure_normalizes_the_long_term_effects_of_maternal_stress_on_post_operative_pain_in_Sprague_Dawley_rat_offspring_ L2 - https://dx.plos.org/10.1371/journal.pone.0057608 DB - PRIME DP - Unbound Medicine ER -