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Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R Study.
Eur J Clin Nutr. 2013 Apr; 67(4):353-9.EJ

Abstract

BACKGROUND/OBJECTIVES

Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life.

METHODS

In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires.

RESULTS

Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean- or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total- or lean-fish consumption was not.

CONCLUSIONS

During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms.

Authors+Show Affiliations

The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23443828

Citation

Leermakers, E T M., et al. "Maternal Fish Consumption During Pregnancy and Risks of Wheezing and Eczema in Childhood: the Generation R Study." European Journal of Clinical Nutrition, vol. 67, no. 4, 2013, pp. 353-9.
Leermakers ET, Sonnenschein-van der Voort AM, Heppe DH, et al. Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R Study. Eur J Clin Nutr. 2013;67(4):353-9.
Leermakers, E. T., Sonnenschein-van der Voort, A. M., Heppe, D. H., de Jongste, J. C., Moll, H. A., Franco, O. H., Hofman, A., Jaddoe, V. W., & Duijts, L. (2013). Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R Study. European Journal of Clinical Nutrition, 67(4), 353-9. https://doi.org/10.1038/ejcn.2013.36
Leermakers ET, et al. Maternal Fish Consumption During Pregnancy and Risks of Wheezing and Eczema in Childhood: the Generation R Study. Eur J Clin Nutr. 2013;67(4):353-9. PubMed PMID: 23443828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R Study. AU - Leermakers,E T M, AU - Sonnenschein-van der Voort,A M M, AU - Heppe,D H M, AU - de Jongste,J C, AU - Moll,H A, AU - Franco,O H, AU - Hofman,A, AU - Jaddoe,V W V, AU - Duijts,L, Y1 - 2013/02/27/ PY - 2013/2/28/entrez PY - 2013/2/28/pubmed PY - 2013/10/30/medline SP - 353 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 67 IS - 4 N2 - BACKGROUND/OBJECTIVES: Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life. METHODS: In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires. RESULTS: Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean- or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total- or lean-fish consumption was not. CONCLUSIONS: During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/23443828/Maternal_fish_consumption_during_pregnancy_and_risks_of_wheezing_and_eczema_in_childhood:_the_Generation_R_Study_ L2 - https://doi.org/10.1038/ejcn.2013.36 DB - PRIME DP - Unbound Medicine ER -