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Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes.
Acta Psychiatr Scand. 2014 Jan; 129(1):54-62.AP

Abstract

OBJECTIVE

To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.

METHOD

Psychotic experiences (PEs), childhood abuse, cannabis use and COMT Val158Met genotypes were assessed in 533 individuals from the general population. Data were analysed hierarchically by means of multiple linear regression models.

RESULTS

Childhood abuse showed a significant main effect on both positive (β = 0.09; SE = 0.04; P = 0.047) and negative PEs (β = 0.11; SE = 0.05; P = 0.038). A significant three-way interaction effect was found among childhood abuse, cannabis use and the COMT gene on positive PEs (β = -0.30; SE = 0.11; P = 0.006). This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. Furthermore, exposure to childhood abuse and cannabis use increased PE scores in Val carriers. However, in individuals exposed to childhood abuse but who did not use cannabis, PEs increased as a function of the Met allele copies of the COMT gene.

CONCLUSION

Cannabis use after exposure to childhood abuse may have opposite effects on the risk of PEs, depending on the COMT genotypes providing evidence for a qualitative interaction. Val carriers exposed to childhood abuse are vulnerable to the psychosis-inducing effects of cannabis.

Authors+Show Affiliations

Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23445265

Citation

Alemany, S, et al. "Psychosis-inducing Effects of Cannabis Are Related to Both Childhood Abuse and COMT Genotypes." Acta Psychiatrica Scandinavica, vol. 129, no. 1, 2014, pp. 54-62.
Alemany S, Arias B, Fatjó-Vilas M, et al. Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatr Scand. 2014;129(1):54-62.
Alemany, S., Arias, B., Fatjó-Vilas, M., Villa, H., Moya, J., Ibáñez, M. I., Ortet, G., Gastó, C., & Fañanás, L. (2014). Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatrica Scandinavica, 129(1), 54-62. https://doi.org/10.1111/acps.12108
Alemany S, et al. Psychosis-inducing Effects of Cannabis Are Related to Both Childhood Abuse and COMT Genotypes. Acta Psychiatr Scand. 2014;129(1):54-62. PubMed PMID: 23445265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. AU - Alemany,S, AU - Arias,B, AU - Fatjó-Vilas,M, AU - Villa,H, AU - Moya,J, AU - Ibáñez,M I, AU - Ortet,G, AU - Gastó,C, AU - Fañanás,L, Y1 - 2013/02/28/ PY - 2013/01/28/accepted PY - 2013/3/1/entrez PY - 2013/3/1/pubmed PY - 2014/9/2/medline KW - cannabis KW - genetics KW - psychoses KW - trauma SP - 54 EP - 62 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 129 IS - 1 N2 - OBJECTIVE: To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene. METHOD: Psychotic experiences (PEs), childhood abuse, cannabis use and COMT Val158Met genotypes were assessed in 533 individuals from the general population. Data were analysed hierarchically by means of multiple linear regression models. RESULTS: Childhood abuse showed a significant main effect on both positive (β = 0.09; SE = 0.04; P = 0.047) and negative PEs (β = 0.11; SE = 0.05; P = 0.038). A significant three-way interaction effect was found among childhood abuse, cannabis use and the COMT gene on positive PEs (β = -0.30; SE = 0.11; P = 0.006). This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. Furthermore, exposure to childhood abuse and cannabis use increased PE scores in Val carriers. However, in individuals exposed to childhood abuse but who did not use cannabis, PEs increased as a function of the Met allele copies of the COMT gene. CONCLUSION: Cannabis use after exposure to childhood abuse may have opposite effects on the risk of PEs, depending on the COMT genotypes providing evidence for a qualitative interaction. Val carriers exposed to childhood abuse are vulnerable to the psychosis-inducing effects of cannabis. SN - 1600-0447 UR - https://www.unboundmedicine.com/medline/citation/23445265/Psychosis_inducing_effects_of_cannabis_are_related_to_both_childhood_abuse_and_COMT_genotypes_ L2 - https://doi.org/10.1111/acps.12108 DB - PRIME DP - Unbound Medicine ER -