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Serum selenium is low in newly diagnosed Graves' disease: a population-based study.
Clin Endocrinol (Oxf) 2013; 79(4):584-90CE

Abstract

CONTEXT

Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.

OBJECTIVE

To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.

DESIGN AND SETTINGS

S-Se was measured in triplicate by a fluorimetric method.

PARTICIPANTS

Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830).

MAIN OUTCOME MEASURE

Differences in s-Se values.

RESULTS

S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).

CONCLUSION

Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.

Authors+Show Affiliations

Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. I.Bulow@rn.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23448365

Citation

Bülow Pedersen, Inge, et al. "Serum Selenium Is Low in Newly Diagnosed Graves' Disease: a Population-based Study." Clinical Endocrinology, vol. 79, no. 4, 2013, pp. 584-90.
Bülow Pedersen I, Knudsen N, Carlé A, et al. Serum selenium is low in newly diagnosed Graves' disease: a population-based study. Clin Endocrinol (Oxf). 2013;79(4):584-90.
Bülow Pedersen, I., Knudsen, N., Carlé, A., Schomburg, L., Köhrle, J., Jørgensen, T., ... Laurberg, P. (2013). Serum selenium is low in newly diagnosed Graves' disease: a population-based study. Clinical Endocrinology, 79(4), pp. 584-90. doi:10.1111/cen.12185.
Bülow Pedersen I, et al. Serum Selenium Is Low in Newly Diagnosed Graves' Disease: a Population-based Study. Clin Endocrinol (Oxf). 2013;79(4):584-90. PubMed PMID: 23448365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum selenium is low in newly diagnosed Graves' disease: a population-based study. AU - Bülow Pedersen,Inge, AU - Knudsen,Nils, AU - Carlé,Allan, AU - Schomburg,Lutz, AU - Köhrle,Josef, AU - Jørgensen,Torben, AU - Rasmussen,Lone Banke, AU - Ovesen,Lars, AU - Laurberg,Peter, Y1 - 2013/03/27/ PY - 2012/11/26/received PY - 2013/01/30/revised PY - 2013/02/11/revised PY - 2013/02/13/accepted PY - 2013/3/2/entrez PY - 2013/3/2/pubmed PY - 2014/4/5/medline SP - 584 EP - 90 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 79 IS - 4 N2 - CONTEXT: Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. OBJECTIVE: To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. DESIGN AND SETTINGS: S-Se was measured in triplicate by a fluorimetric method. PARTICIPANTS: Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830). MAIN OUTCOME MEASURE: Differences in s-Se values. RESULTS: S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27). CONCLUSION: Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/23448365/Serum_selenium_is_low_in_newly_diagnosed_Graves'_disease:_a_population_based_study_ L2 - https://doi.org/10.1111/cen.12185 DB - PRIME DP - Unbound Medicine ER -