Tags

Type your tag names separated by a space and hit enter

Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus.
J Virol. 2013 May; 87(9):5300-4.JV

Abstract

Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.

Authors+Show Affiliations

Institute for Virology, Philipps University Marburg, Marburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23449793

Citation

Zielecki, Florian, et al. "Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus." Journal of Virology, vol. 87, no. 9, 2013, pp. 5300-4.
Zielecki F, Weber M, Eickmann M, et al. Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. J Virol. 2013;87(9):5300-4.
Zielecki, F., Weber, M., Eickmann, M., Spiegelberg, L., Zaki, A. M., Matrosovich, M., Becker, S., & Weber, F. (2013). Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. Journal of Virology, 87(9), 5300-4. https://doi.org/10.1128/JVI.03496-12
Zielecki F, et al. Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus. J Virol. 2013;87(9):5300-4. PubMed PMID: 23449793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. AU - Zielecki,Florian, AU - Weber,Michaela, AU - Eickmann,Markus, AU - Spiegelberg,Larissa, AU - Zaki,Ali Moh, AU - Matrosovich,Mikhail, AU - Becker,Stephan, AU - Weber,Friedemann, Y1 - 2013/02/28/ PY - 2013/3/2/entrez PY - 2013/3/2/pubmed PY - 2013/7/9/medline SP - 5300 EP - 4 JF - Journal of virology JO - J. Virol. VL - 87 IS - 9 N2 - Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/23449793/Human_cell_tropism_and_innate_immune_system_interactions_of_human_respiratory_coronavirus_EMC_compared_to_those_of_severe_acute_respiratory_syndrome_coronavirus_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=23449793 DB - PRIME DP - Unbound Medicine ER -