Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim.J Clin Apher. 2013 Aug; 28(4):321-4.JC
Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is little experience when using this drug before splenectomy. We describe herein the case of a young female with chronic ITP who was treated with romiplostim, underwent splenectomy shortly thereafter, and required plateletpheresis for postoperative rebound thrombocytosis with concomitant neurologic symptoms.
Links
MeSH
Pub Type(s)
Case Reports
Journal Article
Language
eng
PubMed ID
23450778
Citation
Raval, Jay S., et al. "Plateletpheresis for Postsplenectomy Rebound Thrombocytosis in a Patient With Chronic Immune Thrombocytopenic Purpura On Romiplostim." Journal of Clinical Apheresis, vol. 28, no. 4, 2013, pp. 321-4.
Raval JS, Redner RL, Kiss JE. Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. J Clin Apher. 2013;28(4):321-4.
Raval, J. S., Redner, R. L., & Kiss, J. E. (2013). Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. Journal of Clinical Apheresis, 28(4), 321-4. https://doi.org/10.1002/jca.21254
Raval JS, Redner RL, Kiss JE. Plateletpheresis for Postsplenectomy Rebound Thrombocytosis in a Patient With Chronic Immune Thrombocytopenic Purpura On Romiplostim. J Clin Apher. 2013;28(4):321-4. PubMed PMID: 23450778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim.
AU - Raval,Jay S,
AU - Redner,Robert L,
AU - Kiss,Joseph E,
Y1 - 2013/03/01/
PY - 2012/10/02/received
PY - 2012/12/22/revised
PY - 2013/01/14/accepted
PY - 2013/3/2/entrez
PY - 2013/3/2/pubmed
PY - 2014/4/4/medline
KW - ITP
KW - immune thrombocytopenic purpura
KW - plateletpheresis
KW - romiplostim
KW - splenectomy
SP - 321
EP - 4
JF - Journal of clinical apheresis
JO - J Clin Apher
VL - 28
IS - 4
N2 - Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is little experience when using this drug before splenectomy. We describe herein the case of a young female with chronic ITP who was treated with romiplostim, underwent splenectomy shortly thereafter, and required plateletpheresis for postoperative rebound thrombocytosis with concomitant neurologic symptoms.
SN - 1098-1101
UR - https://www.unboundmedicine.com/medline/citation/23450778/Plateletpheresis_for_postsplenectomy_rebound_thrombocytosis_in_a_patient_with_chronic_immune_thrombocytopenic_purpura_on_romiplostim_
L2 - https://doi.org/10.1002/jca.21254
DB - PRIME
DP - Unbound Medicine
ER -