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Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim.
J Clin Apher. 2013 Aug; 28(4):321-4.JC

Abstract

Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is little experience when using this drug before splenectomy. We describe herein the case of a young female with chronic ITP who was treated with romiplostim, underwent splenectomy shortly thereafter, and required plateletpheresis for postoperative rebound thrombocytosis with concomitant neurologic symptoms.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. jay_raval@med.unc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23450778

Citation

Raval, Jay S., et al. "Plateletpheresis for Postsplenectomy Rebound Thrombocytosis in a Patient With Chronic Immune Thrombocytopenic Purpura On Romiplostim." Journal of Clinical Apheresis, vol. 28, no. 4, 2013, pp. 321-4.
Raval JS, Redner RL, Kiss JE. Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. J Clin Apher. 2013;28(4):321-4.
Raval, J. S., Redner, R. L., & Kiss, J. E. (2013). Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. Journal of Clinical Apheresis, 28(4), 321-4. https://doi.org/10.1002/jca.21254
Raval JS, Redner RL, Kiss JE. Plateletpheresis for Postsplenectomy Rebound Thrombocytosis in a Patient With Chronic Immune Thrombocytopenic Purpura On Romiplostim. J Clin Apher. 2013;28(4):321-4. PubMed PMID: 23450778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim. AU - Raval,Jay S, AU - Redner,Robert L, AU - Kiss,Joseph E, Y1 - 2013/03/01/ PY - 2012/10/02/received PY - 2012/12/22/revised PY - 2013/01/14/accepted PY - 2013/3/2/entrez PY - 2013/3/2/pubmed PY - 2014/4/4/medline KW - ITP KW - immune thrombocytopenic purpura KW - plateletpheresis KW - romiplostim KW - splenectomy SP - 321 EP - 4 JF - Journal of clinical apheresis JO - J Clin Apher VL - 28 IS - 4 N2 - Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is little experience when using this drug before splenectomy. We describe herein the case of a young female with chronic ITP who was treated with romiplostim, underwent splenectomy shortly thereafter, and required plateletpheresis for postoperative rebound thrombocytosis with concomitant neurologic symptoms. SN - 1098-1101 UR - https://www.unboundmedicine.com/medline/citation/23450778/Plateletpheresis_for_postsplenectomy_rebound_thrombocytosis_in_a_patient_with_chronic_immune_thrombocytopenic_purpura_on_romiplostim_ L2 - https://doi.org/10.1002/jca.21254 DB - PRIME DP - Unbound Medicine ER -