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HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c).
J Diabetes. 2013 Sep; 5(3):282-90.JD

Abstract

OBJECTIVE

To identify the optimal threshold of HbA1c and to evaluate the predictive performance of HbA1c levels in diagnosing diabetes and prediabetes in a middle-aged and elderly Han Chinese population from northwest China.

METHODS

In all, 3354 participants aged ≥ 40 years with no history of diabetes from northwest China were enrolled in the present cross-sectional study. All subjects underwent a 75-g oral glucose tolerance test (OGTT), as well as HbA1c testing. HbA1c thresholds for diagnosing diabetes and prediabetes were identified by the highest sum of sensitivity and specificity of each cut-off point, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy of the HbA1c threshold.

RESULTS

The mean (± SD) age of the participants was 57 ± 8 years, and 70.75% were women. Based on results of the OGTT, 1347 (40.16%) subjects had impaired fasting glucose and/or impaired glucose tolerance, and 725 (21.62%) had diabetes. The area under the ROC curve for detecting undiagnosed diabetes and prediabetes by HbA1c levels was 0.810 (95% confidence interval [CI] 0.796-0.823) and 0.732 (95% CI 0.717-0.747), respectively. HbA1c threshold of 6.4% and 6.1% produced the highest sum of sensitivity (60.00% and 61.49%) and specificity (87.33% and 73.24%) for diagnosing diabetes and prediabetes, respectively.

CONCLUSION

HbA1c is an effective and convenient method for diagnosing diabetes and prediabetes. HbA1c thresholds of 6.4% and 6.1% may be used as diagnostic criteria for diabetes and prediabetes, respectively, in the Han Chinese population living in northwest China.

Authors+Show Affiliations

Department of Diabetes, Karamay People's Hospital, Karamay, Xinjiang Uygur Autonomous Region, China. niuyoumou@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23452328

Citation

Wu, Shengli, et al. "HbA1c and the Diagnosis of Diabetes and Prediabetes in a Middle-aged and Elderly Han Population From Northwest China (HbA1c)." Journal of Diabetes, vol. 5, no. 3, 2013, pp. 282-90.
Wu S, Yi F, Zhou C, et al. HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c). J Diabetes. 2013;5(3):282-90.
Wu, S., Yi, F., Zhou, C., Zhang, M., Zhu, Y., Tuniyazi, Y., Huang, L., Huang, X., Wang, F., Bi, Y., & Ning, G. (2013). HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c). Journal of Diabetes, 5(3), 282-90. https://doi.org/10.1111/1753-0407.12035
Wu S, et al. HbA1c and the Diagnosis of Diabetes and Prediabetes in a Middle-aged and Elderly Han Population From Northwest China (HbA1c). J Diabetes. 2013;5(3):282-90. PubMed PMID: 23452328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c). AU - Wu,Shengli, AU - Yi,Fengshou, AU - Zhou,Chao, AU - Zhang,Mintao, AU - Zhu,Yujing, AU - Tuniyazi,Yilihamu, AU - Huang,Lijuan, AU - Huang,Xuefang, AU - Wang,Fugang, AU - Bi,Yufang, AU - Ning,Guang, Y1 - 2013/05/28/ PY - 2012/04/26/received PY - 2013/01/22/revised PY - 2013/02/18/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2014/3/13/medline KW - HbA1c threshold KW - diabetes KW - prediabetes KW - 糖尿病,糖化血红蛋白A1c诊断切点,糖尿病前期 SP - 282 EP - 90 JF - Journal of diabetes JO - J Diabetes VL - 5 IS - 3 N2 - OBJECTIVE: To identify the optimal threshold of HbA1c and to evaluate the predictive performance of HbA1c levels in diagnosing diabetes and prediabetes in a middle-aged and elderly Han Chinese population from northwest China. METHODS: In all, 3354 participants aged ≥ 40 years with no history of diabetes from northwest China were enrolled in the present cross-sectional study. All subjects underwent a 75-g oral glucose tolerance test (OGTT), as well as HbA1c testing. HbA1c thresholds for diagnosing diabetes and prediabetes were identified by the highest sum of sensitivity and specificity of each cut-off point, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy of the HbA1c threshold. RESULTS: The mean (± SD) age of the participants was 57 ± 8 years, and 70.75% were women. Based on results of the OGTT, 1347 (40.16%) subjects had impaired fasting glucose and/or impaired glucose tolerance, and 725 (21.62%) had diabetes. The area under the ROC curve for detecting undiagnosed diabetes and prediabetes by HbA1c levels was 0.810 (95% confidence interval [CI] 0.796-0.823) and 0.732 (95% CI 0.717-0.747), respectively. HbA1c threshold of 6.4% and 6.1% produced the highest sum of sensitivity (60.00% and 61.49%) and specificity (87.33% and 73.24%) for diagnosing diabetes and prediabetes, respectively. CONCLUSION: HbA1c is an effective and convenient method for diagnosing diabetes and prediabetes. HbA1c thresholds of 6.4% and 6.1% may be used as diagnostic criteria for diabetes and prediabetes, respectively, in the Han Chinese population living in northwest China. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/23452328/HbA1c_and_the_diagnosis_of_diabetes_and_prediabetes_in_a_middle_aged_and_elderly_Han_population_from_northwest_China__HbA1c__ L2 - https://doi.org/10.1111/1753-0407.12035 DB - PRIME DP - Unbound Medicine ER -