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Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children.
J Allergy Clin Immunol. 2013 Mar; 131(3):736-42.JA

Abstract

BACKGROUND

Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.

OBJECTIVES

We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children.

METHODS

The Columbia Center for Children's Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years.

RESULTS

Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively).

CONCLUSIONS

This is the first report of an association between postnatal urinary BPA concentrations and asthma in children.

Authors+Show Affiliations

Division of Pulmonary, Allergy and Critical Care, Columbia University School of Physicians and Surgeons, New York, NY, USA. Kd2128@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23452902

Citation

Donohue, Kathleen M., et al. "Prenatal and Postnatal Bisphenol a Exposure and Asthma Development Among Inner-city Children." The Journal of Allergy and Clinical Immunology, vol. 131, no. 3, 2013, pp. 736-42.
Donohue KM, Miller RL, Perzanowski MS, et al. Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children. J Allergy Clin Immunol. 2013;131(3):736-42.
Donohue, K. M., Miller, R. L., Perzanowski, M. S., Just, A. C., Hoepner, L. A., Arunajadai, S., Canfield, S., Resnick, D., Calafat, A. M., Perera, F. P., & Whyatt, R. M. (2013). Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children. The Journal of Allergy and Clinical Immunology, 131(3), 736-42. https://doi.org/10.1016/j.jaci.2012.12.1573
Donohue KM, et al. Prenatal and Postnatal Bisphenol a Exposure and Asthma Development Among Inner-city Children. J Allergy Clin Immunol. 2013;131(3):736-42. PubMed PMID: 23452902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children. AU - Donohue,Kathleen M, AU - Miller,Rachel L, AU - Perzanowski,Matthew S, AU - Just,Allan C, AU - Hoepner,Lori A, AU - Arunajadai,Srikesh, AU - Canfield,Stephen, AU - Resnick,David, AU - Calafat,Antonia M, AU - Perera,Frederica P, AU - Whyatt,Robin M, PY - 2012/06/18/received PY - 2012/12/20/revised PY - 2012/12/24/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2013/4/20/medline SP - 736 EP - 42 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 131 IS - 3 N2 - BACKGROUND: Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation. OBJECTIVES: We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children. METHODS: The Columbia Center for Children's Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years. RESULTS: Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively). CONCLUSIONS: This is the first report of an association between postnatal urinary BPA concentrations and asthma in children. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/23452902/Prenatal_and_postnatal_bisphenol_A_exposure_and_asthma_development_among_inner_city_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(13)00060-2 DB - PRIME DP - Unbound Medicine ER -