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Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats.
Phytomedicine. 2013 May 15; 20(7):577-84.P

Abstract

The study was undertaken to evaluate the antidiabetic effect of green tea extract on carbohydrate metabolic key enzymes in control and streptozotocin high fat diet -induced diabetic rats. The daily oral treatment of green tea extract (300 mg/kg body weight) to diabetic rats for 30 days resulted in a significant reduction in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver of diabetic rats were significantly reverted to near normal levels by the administration of green tea extract. Further, green tea extract administration to diabetic rats improved muscle and hepatic glycogen content suggesting the antihyperglycemic potential of green tea extract in diabetic rats. The obtained results were compared with metformin, a standard oral hypoglycemic drug. Thus, this study indicates that the administration of green tea extract to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels.

Authors+Show Affiliations

Department of Medical Biochemistry, Dr ALM P-G, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23453307

Citation

Sundaram, Ramalingam, et al. "Modulatory Effect of Green Tea Extract On Hepatic Key Enzymes of Glucose Metabolism in Streptozotocin and High Fat Diet Induced Diabetic Rats." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 20, no. 7, 2013, pp. 577-84.
Sundaram R, Naresh R, Shanthi P, et al. Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine. 2013;20(7):577-84.
Sundaram, R., Naresh, R., Shanthi, P., & Sachdanandam, P. (2013). Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 20(7), 577-84. https://doi.org/10.1016/j.phymed.2013.01.006
Sundaram R, et al. Modulatory Effect of Green Tea Extract On Hepatic Key Enzymes of Glucose Metabolism in Streptozotocin and High Fat Diet Induced Diabetic Rats. Phytomedicine. 2013 May 15;20(7):577-84. PubMed PMID: 23453307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. AU - Sundaram,Ramalingam, AU - Naresh,Rajendran, AU - Shanthi,Palanivelu, AU - Sachdanandam,Panchanatham, Y1 - 2013/02/28/ PY - 2012/10/23/received PY - 2012/12/14/revised PY - 2013/01/26/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2013/12/16/medline SP - 577 EP - 84 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 20 IS - 7 N2 - The study was undertaken to evaluate the antidiabetic effect of green tea extract on carbohydrate metabolic key enzymes in control and streptozotocin high fat diet -induced diabetic rats. The daily oral treatment of green tea extract (300 mg/kg body weight) to diabetic rats for 30 days resulted in a significant reduction in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver of diabetic rats were significantly reverted to near normal levels by the administration of green tea extract. Further, green tea extract administration to diabetic rats improved muscle and hepatic glycogen content suggesting the antihyperglycemic potential of green tea extract in diabetic rats. The obtained results were compared with metformin, a standard oral hypoglycemic drug. Thus, this study indicates that the administration of green tea extract to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/23453307/Modulatory_effect_of_green_tea_extract_on_hepatic_key_enzymes_of_glucose_metabolism_in_streptozotocin_and_high_fat_diet_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(13)00037-8 DB - PRIME DP - Unbound Medicine ER -