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Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults.
Int J Cardiol. 2013 Oct 03; 168(3):2141-5.IJ

Abstract

BACKGROUND

The hypertriglyceridemic waist phenotype (defined using both elevated waist circumference and triglycerides) and visceral adiposity index (VAI, defined using waist circumference, body mass index, triglycerides, and high-density lipoprotein cholesterol) have been suggested to be inexpensive yet effective markers of visceral (intra-abdominal) obesity and related dysmetabolic state. These markers may be particularly useful to Asian populations who generally have a low body weight but are prone to visceral adiposity.

METHODS

We examined associations of the hypertriglyceridemic waist phenotype and VAI with risk of coronary heart disease (CHD) in a nested case-control study conducted within two prospective cohort studies of Chinese adults. We identified 355 incident cases of CHD and 697 controls matched for sex, age, and date and time of baseline sample collection. Anthropometric and lipid measurements were performed and used to define the hypertriglyceridemic waist phenotype and VAI according to published methods. Conditional logistic regression was used to evaluate the associations.

RESULTS

Cases had a higher prevalence of the hypertriglyceridemic waist phenotype and higher VAI score than controls in both sexes. Adjusted odds ratios of CHD associated with hypertriglyceridemic waist were 5.18 (95% CI, 2.46-10.9) and 4.63 (2.03-10.5) for women and men, respectively. Adjusted odds ratios of CHD comparing the highest vs. lowest quartile of VAI were 4.44 (95% CI, 2.24-8.82) and 4.23 (1.99-9.00) for women and men, respectively.

CONCLUSION

Our study demonstrates, for the first time, that the hypertriglyceridemic waist phenotype and high VAI score are associated with substantially elevated risk of CHD in Chinese men and women.

Authors+Show Affiliations

Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: xianglan.zhang@vanderbilt.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23453877

Citation

Zhang, Xianglan, et al. "Visceral Adiposity and Risk of Coronary Heart Disease in Relatively Lean Chinese Adults." International Journal of Cardiology, vol. 168, no. 3, 2013, pp. 2141-5.
Zhang X, Shu XO, Li H, et al. Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults. Int J Cardiol. 2013;168(3):2141-5.
Zhang, X., Shu, X. O., Li, H., Yang, G., Xiang, Y. B., Cai, Q., Ji, B. T., Gao, Y. T., & Zheng, W. (2013). Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults. International Journal of Cardiology, 168(3), 2141-5. https://doi.org/10.1016/j.ijcard.2013.01.275
Zhang X, et al. Visceral Adiposity and Risk of Coronary Heart Disease in Relatively Lean Chinese Adults. Int J Cardiol. 2013 Oct 3;168(3):2141-5. PubMed PMID: 23453877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults. AU - Zhang,Xianglan, AU - Shu,Xiao-Ou, AU - Li,Honglan, AU - Yang,Gong, AU - Xiang,Yong-Bing, AU - Cai,Qiuyin, AU - Ji,Bu-Tian, AU - Gao,Yu-Tang, AU - Zheng,Wei, Y1 - 2013/03/01/ PY - 2012/07/18/received PY - 2012/11/28/revised PY - 2013/01/18/accepted PY - 2013/3/5/entrez PY - 2013/3/5/pubmed PY - 2014/12/17/medline KW - Chinese KW - Heart disease KW - Visceral adiposity SP - 2141 EP - 5 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 168 IS - 3 N2 - BACKGROUND: The hypertriglyceridemic waist phenotype (defined using both elevated waist circumference and triglycerides) and visceral adiposity index (VAI, defined using waist circumference, body mass index, triglycerides, and high-density lipoprotein cholesterol) have been suggested to be inexpensive yet effective markers of visceral (intra-abdominal) obesity and related dysmetabolic state. These markers may be particularly useful to Asian populations who generally have a low body weight but are prone to visceral adiposity. METHODS: We examined associations of the hypertriglyceridemic waist phenotype and VAI with risk of coronary heart disease (CHD) in a nested case-control study conducted within two prospective cohort studies of Chinese adults. We identified 355 incident cases of CHD and 697 controls matched for sex, age, and date and time of baseline sample collection. Anthropometric and lipid measurements were performed and used to define the hypertriglyceridemic waist phenotype and VAI according to published methods. Conditional logistic regression was used to evaluate the associations. RESULTS: Cases had a higher prevalence of the hypertriglyceridemic waist phenotype and higher VAI score than controls in both sexes. Adjusted odds ratios of CHD associated with hypertriglyceridemic waist were 5.18 (95% CI, 2.46-10.9) and 4.63 (2.03-10.5) for women and men, respectively. Adjusted odds ratios of CHD comparing the highest vs. lowest quartile of VAI were 4.44 (95% CI, 2.24-8.82) and 4.23 (1.99-9.00) for women and men, respectively. CONCLUSION: Our study demonstrates, for the first time, that the hypertriglyceridemic waist phenotype and high VAI score are associated with substantially elevated risk of CHD in Chinese men and women. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/23453877/Visceral_adiposity_and_risk_of_coronary_heart_disease_in_relatively_lean_Chinese_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(13)00354-9 DB - PRIME DP - Unbound Medicine ER -